Neurochemical Research

, Volume 35, Issue 3, pp 418–428

Alpha Lipoic Acid Alleviates Oxidative Stress and Preserves Blood Brain Permeability in Rats with Subarachnoid Hemorrhage

  • Mehmet Erşahin
  • Hale Z. Toklu
  • Şule Çetinel
  • Meral Yüksel
  • Can Erzik
  • M. Zafer Berkman
  • Berrak Ç. Yeğen
  • Göksel Şener
Original Paper

DOI: 10.1007/s11064-009-0072-z

Cite this article as:
Erşahin, M., Toklu, H.Z., Çetinel, Ş. et al. Neurochem Res (2010) 35: 418. doi:10.1007/s11064-009-0072-z
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Abstract

The neuroprotective effect of alpha lipoic acid (ALA; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (SAH) was assessed in Wistar albino rats. Neurological examination scores recorded at the 48th h of SAH induction were increased in SAH groups, which were accompanied with significant increases in the formation of reactive oxygen species, DNA fragmentation ratios, malondialdehyde levels and myeloperoxidase activity, while significant decreases in the brain glutathione content and Na+, K+-ATPase activity were observed. On the other hand, ALA treatment reversed all these biochemical indices as well as SAH-induced histopathological alterations. Increased brain edema, impaired blood-brain-barrier permeability and neurological scores were also improved by ALA treatment. The results demonstrate that ALA exerts neuroprotective effects via the enhancement of endogenous antioxidant enzyme activity, the inhibition of neutrophil accumulation and free radical generation, suggesting a therapeutic potential in reducing secondary injury after SAH in patients.

Keywords

Alpha lipoic acid Antioxidant Cerebral vasospasm Subarachnoid hemorrhage Lipid peroxidation 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Mehmet Erşahin
    • 1
  • Hale Z. Toklu
    • 2
  • Şule Çetinel
    • 3
  • Meral Yüksel
    • 4
  • Can Erzik
    • 5
  • M. Zafer Berkman
    • 1
  • Berrak Ç. Yeğen
    • 6
  • Göksel Şener
    • 2
  1. 1.Department of NeurosurgeryHaydarpasa Numune Education and Research HospitalIstanbulTurkey
  2. 2.Department of Pharmacology, School of PharmacyMarmara UniversityIstanbulTurkey
  3. 3.Department of Histology & Embryology, School of MedicineMarmara UniversityIstanbulTurkey
  4. 4.Vocational School of Health Related ProfessionsMarmara UniversityIstanbulTurkey
  5. 5.Department of Medical Biology, School of MedicineMarmara UniversityIstanbulTurkey
  6. 6.Department of Physiology, School of MedicineMarmara UniversityIstanbulTurkey

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