Neurochemical Research

, Volume 34, Issue 4, pp 601–629

Dopamine and Aging: Intersecting Facets

Review Article

DOI: 10.1007/s11064-008-9858-7

Cite this article as:
Rollo, C.D. Neurochem Res (2009) 34: 601. doi:10.1007/s11064-008-9858-7

Abstract

Aging encompasses life itself so understanding requires frameworks that forge unity amidst complexity. The free radical theory of aging is one example. The original focus on damage was augmented recently by appreciation that reactive oxygen and nitrogen species are essential to normal signaling and cell function. This paradigm is currently undergoing an explosive expansion fueled by the discovery that regulatory organization is a merry-go-round of redox cycling seamlessly fused to endogenous clocks. This might best be described as an “Electroplasmic Cycle.” This is certainly applicable to dopaminergic neurons with their exceptional metabolic, electrical and rhythmic properties. Here I review normal aging of dopamine systems to highlight them as a valuable model. I then examine the possible integration of free radical and ion channel theories of aging. Finally, I incorporate clocks and explore the multifaceted implications of electroplasmic cycles with special emphasis on dopamine.

Keywords

DopamineAgingLongevityRedoxFree radicalsIon channelsClocksRegulationElectroplasmic cycleEvolutionary theory

Abbreviations

ATr1

Angiotensin receptor 1

CBP

CREB binding protein

Cry

Cryptochrome

DA

Dopamine

DAT

Dopamine transport and reuptake protein

DAr1

Dopamine receptor 1

DAr2

Dopamine receptor 2

ER

Endoplasmic reticulum

GH

Growth hormone

GHRH

Growth hormone releasing hormone

GSH

Reduced glutathione

GSH-S-TR

Glutathione S-transferase

GSSG

Oxidized glutathione

HO-1

Heme oxygenase 1

HPA

Hypothalamic–pituitary–adrenal axis

HVA

Homovanillic acid

IGF-1

Insulin-like growth factor 1

L-DOPA

l-Dihydroxyphenylalanine

LTP

Long-term potentiation

MAO

Monoamine oxidase

NE

Norepinephrine

NO

Nitric oxide

NOS

Nitric oxide synthase

NOX

NAD(P)H oxidases

NPAS2

Neuronal PAS domain protein 2

PD

Parkinson’s disease

Per

Period

PKA

Protein kinase A

RONS

Reactive oxygen and nitrogen species

SAM

S-adenosylhomocysteine

SN

Substantia nigra

SOR

Superoxide

SOD

Superoxide dismutase

SCN

Suprachiasmatic nuclei

SUR

Sulfonylurea receptors

TN

Tyrosine hydroxylase

VMAT2

Vesicular monoamine transporter 2

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.LSB-226, Department of BiologyMcMaster UniversityHamiltonCanada