Neurochemical Research

, Volume 34, Issue 3, pp 470–479

Characterization of Phenytoin, Carbamazepine, Vinpocetine and Clorgyline Simultaneous Effects on Sodium Channels and Catecholamine Metabolism in Rat Striatal Nerve Endings

  • María Sitges
  • Blanca I. Aldana
  • Luz M. Chiu
  • Vladimir Nekrassov
Original Paper

DOI: 10.1007/s11064-008-9805-7

Cite this article as:
Sitges, M., Aldana, B.I., Chiu, L.M. et al. Neurochem Res (2009) 34: 470. doi:10.1007/s11064-008-9805-7

Abstract

The effects of two classic antiepileptic drugs (carbamazepine and phenytoin), a potential antiepileptic (vinpocetine) and a monoamine-oxidase inhibitor (clorgyline) on the simultaneous changes (detected by HPLC) on Glu, Asp, dopamine and DOPAC inside and outside striatal isolated nerve endings were investigated. Under resting conditions phenytoin, carbamazepine and clorgyline increased dopamine release. Phenytoin and clorgyline increased internal dopamine and decreased DOPAC formation. Carbamazepine decreased internal dopamine and practically did not change DOPAC formation. Glu and Asp release was unchanged. Neurotransmitter release induced by the Na+ channel opener veratridine was reduced by all the antiepileptic drugs tested, except phenytoin which, like clorgyline, facilitated veratridine-induced dopamine release. We conclude that besides the antagonism exerted by carbamazepine, phenytoin and vinpocetine on excitatory neurotransmitters release triggered by Na+ channel activation, that might importantly contribute to their anticonvulsant action, they exert different actions on striatal dopamine distribution, that might explain their different side effect profiles.

Keywords

Antiepileptic drugs Monoamino-oxidase Dopamine DOPAC Glutamate Aspartate Veratridine 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • María Sitges
    • 1
  • Blanca I. Aldana
    • 1
  • Luz M. Chiu
    • 1
  • Vladimir Nekrassov
    • 2
  1. 1.Depto. de Biología Celular y FisiologíaInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de MéxicoMexicoMexico
  2. 2.División de Investigación Básica y AplicadaInstituto Nacional de Rehabilitación, SSAMexicoMexico

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