, Volume 33, Issue 10, pp 1979-1989
Date: 07 May 2008

Characteristics of HCN Channels and Their Participation in Neuropathic Pain

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Neuropathic pain is induced by the injury to nervous systems and characterized by hyperalgesia, allodynia and spontaneous pain. The underlying mechanisms include peripheral and central sensitization resulted from neuronal hyperexcitability. A number of ion channels are considered to contribute to the neuronal hyperexcitability. Here, we particularly concentrate on an interesting ion channel, hyperpolarization-activated cyclic nucleotide gated (HCN) channels. We overview its biophysical properties, physiological functions, followed by focusing on the current progress in the study of its role in the development of neuropathic pain. We attempt to provide a comprehensive review of the potential valuable target, HCN channels, in the treatment of neuropathic pain.

Special issue article in honor of Dr. Ji-Sheng Han.
Yu-Qiu Jiang, Qian Sun, and Hui-Yin Tu—contributed equally to this paper.