Neurochemical Research

, Volume 33, Issue 11, pp 2171–2177

The Septic Brain

Authors

  • Emilio L. Streck
    • Laboratório de Fisiopatologia Experimental, Programa de Pós-graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da SaúdeUniversidade do Extremo Sul Catarinense
  • Clarissa M. Comim
    • Laboratório de Neurociências, Programa de Pós-graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da SaúdeUniversidade do Extremo Sul Catarinense
  • Tatiana Barichello
    • Laboratório de Fisiopatologia Experimental, Programa de Pós-graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da SaúdeUniversidade do Extremo Sul Catarinense
    • Laboratório de Neurociências, Programa de Pós-graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da SaúdeUniversidade do Extremo Sul Catarinense
Overview

DOI: 10.1007/s11064-008-9671-3

Cite this article as:
Streck, E.L., Comim, C.M., Barichello, T. et al. Neurochem Res (2008) 33: 2171. doi:10.1007/s11064-008-9671-3

Abstract

Sepsis is a major disease entity with important clinical implications. Sepsis-induced multiple organ failure is associated with a high mortality rate in humans and is clinically characterized by pulmonary, cardiovascular, renal and gastrointestinal dysfunction. Recently, several studies have demonstrated that sepsis survivors present long-term cognitive impairment, including alterations in memory, attention, concentration and/or global loss of cognitive function. However, the pathogenesis and natural history of septic encephalopathy and cognitive impairment are still poorly known and further understanding of these processes is necessary for the development of effective preventive and therapeutic interventions. This review discusses the clinical presentation and underlying pathophysiology of the encephalopathy and cognitive impairment associated with sepsis.

Keywords

SepsisEncephalopathyCognitive impairment

Abbreviations

5HT-1A

Serotonin receptor type 1A

ACTH

Adrenocorticotropic hormone

AMPc

Adenosine monophosphate cyclic

BBB

Blood–brain barrier

BDNF

Brain derived-neurotrofic factor

CLP

Cecal ligation and perforation

CNS

Central nervous system

DFX

Deferoxamine

CREB

cAMP response element-binding

ICU

Intensive care unit

GABAA

Gama-aminobutyric acid receptor type A

LPS

Lipopolysaccharide

MAPK

Mitogen-activated protein kinase

NAC

N-Acetylcysteine

NMDA

N-Methyl-d-aspartic acid

NSE

Neuron-specific enolase

PKA

Protein kinase A

PKC

Protein kinase C

mRNA

Messenger ribonucleic acid

SE

Septic encephalopathy

SIRS

Systemic inflammatory response syndrome

VAChT

Vesicle transporters of acetylcholine

Copyright information

© Springer Science+Business Media, LLC 2008