Neurochemical Research

, Volume 33, Issue 7, pp 1238–1246

Evaluation of Estrogen Neuroprotective Effect on Nigrostriatal Dopaminergic Neurons Following 6-Hydroxydopamine Injection into the Substantia Nigra Pars Compacta or the Medial Forebrain Bundle

  • Anete Curte Ferraz
  • Francesca Matheussi
  • Raphael Escorsim Szawka
  • Vanessa Rizelio
  • Ana Márcia Delattre
  • Paula Rigon
  • Érica do Espírito Santo Hermel
  • Léder Leal Xavier
  • Matilde Achaval
  • Janete A. Anselmo-Franci
Original Paper

DOI: 10.1007/s11064-007-9575-7

Cite this article as:
Ferraz, A.C., Matheussi, F., Szawka, R.E. et al. Neurochem Res (2008) 33: 1238. doi:10.1007/s11064-007-9575-7

Abstract

Studies involving estrogen treatment of ovariectomized rats or mice have attributed to this hormone a neuroprotective effect on the substantia nigra pars compacta (SNpc) neurons. We investigated the effect of estradiol replacement in ovariectomized rats on the survival of dopaminergic mesencephalic cell and the integrity of their projections to the striatum after microinjections of 1 μg of 6-hydroxydopamine (6-OHDA) into the right SNpc or medial forebrain bundle (MFB). Estradiol replacement did not prevent the reduction either in the striatal concentrations of DA and metabolites or in the number of nigrostriatal dopaminergic neurons following lesion with 1 μg of 6-OHDA into the SNpc. Nevertheless, estradiol treatment reduced the decrease in striatal DA following injection of 1 μg of 6-OHDA into the MFB. Results suggest therefore that estrogen protect nigrostriatal dopaminergic neurons against a 6-OHDA injury to the MFB but not the SNpc. This may be due to the distinct degree of lesions promoted in these different rat models of Parkinson’s disease.

Keywords

Neuroprotection6-OHDAParkinson’s diseaseEstrogenSubstantia nigra pars compactaMedial forebrain bundleDopaminergic neurons

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Anete Curte Ferraz
    • 1
  • Francesca Matheussi
    • 1
  • Raphael Escorsim Szawka
    • 2
  • Vanessa Rizelio
    • 1
  • Ana Márcia Delattre
    • 1
  • Paula Rigon
    • 3
  • Érica do Espírito Santo Hermel
    • 3
  • Léder Leal Xavier
    • 4
  • Matilde Achaval
    • 3
  • Janete A. Anselmo-Franci
    • 2
  1. 1.Laboratório de Neurofisiologia, Departamento de FisiologiaUniversidade Federal do ParanáCuritibaBrazil
  2. 2.Laboratório de Neuroendocrinologia, Faculdade de Odontologia de Ribeirão Preto, Departamento de Morfologia, Estomatologia e FisiologiaUniversidade de São PauloRibeirao PretoBrazil
  3. 3.Laboratório de Histofisiologia Comparada, Departamento de Ciências Morfológicas, Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  4. 4.Laboratório de Biologia Tecidual, Departamento de Ciências MorfofisiológicasPUCRSPorto AlegreBrazil