Neurochemical Research

, Volume 33, Issue 5, pp 776–783

Promotion of Neuronal Plasticity by (−)-Epigallocatechin-3-Gallate

  • Wen Xie
  • Narayan Ramakrishna
  • Andrzej Wieraszko
  • Yu-Wen Hwang
Original paper

DOI: 10.1007/s11064-007-9494-7

Cite this article as:
Xie, W., Ramakrishna, N., Wieraszko, A. et al. Neurochem Res (2008) 33: 776. doi:10.1007/s11064-007-9494-7

Abstract

The consumption of (−)-epigallocatechin-3-gallate (EGCG), the major polyphenolic compound found in green tea, has been associated with various neurological benefits including cognitive improvement. The physiological basis for this effect is unknown. In this study, we used synaptic transmission between the CA3 and CA1 regions (Schaffer collateral) of the mouse hippocampus to examine the effects of EGCG on neuronal plasticity. We found that the level of high frequency stimulation-evoked long-term potentiation (LTP) was significantly enhanced when hippocampal slices were pre-incubated with 10 μM EGCG for 1 h prior to the experiment. EGCG incubation also enabled hippocampal slices prepared from Ts65Dn mice, a Down syndrome mouse model deficient in LTP, to express LTP to a level comparable to the normal controls. EGCG treatment did not alter the degree of pair-pulse inhibition; therefore, the enhancement effect of EGCG is unlikely to involve the attenuation of this inhibitory mechanism.

Keywords

LTPEGCGTs65Dn mouseDown syndrome animal modelPaired-pulse inhibitionTea catechinsHippocampal slices

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Wen Xie
    • 1
    • 2
  • Narayan Ramakrishna
    • 4
  • Andrzej Wieraszko
    • 1
    • 2
    • 3
  • Yu-Wen Hwang
    • 1
    • 2
    • 4
  1. 1.CSI/IBR Center for Developmental Neuroscience, College of Staten IslandCity University of New YorkStaten IslandUSA
  2. 2.Doctoral Program in Biology, The Graduate CenterCity University of New YorkNew YorkUSA
  3. 3.Department of BiologyCollege of Staten IslandStaten IslandUSA
  4. 4.Molecular Biology DepartmentNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA