Neurochemical Research

, 32:1665

Iron-Deficiency Anemia is Associated with Altered Characteristics of Sleep Spindles in NREM Sleep in Infancy

  • Patricio Peirano
  • Cecilia Algarín
  • Marcelo Garrido
  • Diógenes Algarín
  • Betsy Lozoff
Original Paper

DOI: 10.1007/s11064-007-9396-8

Cite this article as:
Peirano, P., Algarín, C., Garrido, M. et al. Neurochem Res (2007) 32: 1665. doi:10.1007/s11064-007-9396-8

Abstract

Objective

To determine the effects of iron-deficiency anemia on the development of non-rapid-eye-movement (NREM) sleep stages, as indexed by sleep spindles.

Study design

Patterns of sleep spindles during NREM sleep stages 2 and 3–4 (slow-wave-sleep, SWS) were compared in 26 otherwise healthy 6-month-old Chilean infants with iron-deficiency anemia and 18 non-anemic control infants. From polygraphic recordings, EEG activity was analyzed for sleep spindles to assess their number (density), duration, frequency, and inter-spindle interval.

Results

Iron-deficient anemic infants differed from the control group by having sleep spindles with reduced density, lower frequency, and longer inter-spindle intervals in NREM sleep stage 2 and SWS.

Conclusions

These results provide evidence of delayed sleep spindle patterns in iron-deficient anemic infants, suggesting that iron is an essential micronutrient for the normal progression of NREM sleep pattern development in the human.

Keywords

InfantsIron-deficiency anemiaSleep spindlesNREM sleepNREM sleep stage 2SWS

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Patricio Peirano
    • 1
  • Cecilia Algarín
    • 1
  • Marcelo Garrido
    • 1
  • Diógenes Algarín
    • 1
  • Betsy Lozoff
    • 2
  1. 1.Sleep and Functional Neurobiology Laboratory, Institute of Nutrition and Food Technology (INTA)University of ChileSantiagoChile
  2. 2.Center for Human Growth and Development and the Department of Pediatrics and Communicable DiseasesUniversity of MichiganMichiganUSA