Neurochemical Research

, Volume 32, Issue 6, pp 981–987

Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat

  • Meherzia Mokni
  • Salem Elkahoui
  • Ferid Limam
  • Mohamed Amri
  • Ezzedine Aouani
Original Paper

DOI: 10.1007/s11064-006-9255-z

Cite this article as:
Mokni, M., Elkahoui, S., Limam, F. et al. Neurochem Res (2007) 32: 981. doi:10.1007/s11064-006-9255-z
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Abstract

We have studied the effect of resveratrol on lipoperoxidation and antioxidant enzyme activity level in the brain of healthy rats. When intraperitoneally administered, resveratrol significantly and dose dependently decreased brain malondialdehyde level. Resveratrol also increased in a dose-dependent way brain superoxide dismutase, catalase and peroxidase activities. Optimal effect on antioxidant enzyme and lipoperoxidation products were obtained with resveratrol concentration of 12.5 mg/kg body wt. Native polyacrylamide gel electrophoresis analysis of antioxidant isoenzymes revealed that resveratrol up regulated at least two acidic superoxide dismutase isoforms called A1 and A2, two basic isoforms called B1 and B2. Resveratrol also up regulated two catalase isoforms and a broad peroxidase band corresponding to several isoforms. All these findings suggest that resveratrol is able to cross the blood brain barrier and exerts potent antioxidant features. Resveratrol also exerts neuroprotective properties by up regulating several detoxifying enzymes, most of which are iron proteins.

Keywords

ResveratrolBrainAntioxidant enzymesMDALipoperoxidation

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Meherzia Mokni
    • 1
  • Salem Elkahoui
    • 2
  • Ferid Limam
    • 2
  • Mohamed Amri
    • 1
  • Ezzedine Aouani
    • 2
  1. 1.Laboratoire de Physiologie de la Nutrition, Faculté des Sciences de TunisCampus Universitaire El Manar IITunisTunisia
  2. 2.Laboratoire Interactions Légumineuses-Microorganismes, Centre de BiotechnologieTechnopole Bordj-CedriaHammam-LifTunisia