Neurochemical Research

, Volume 32, Issue 6, pp 965–972

Antioxidant Effects of SelegilIne in Oxidative Stress Induced by Iron Neonatal Treatment in Rats

  • Patrícia Budni
  • Maria Noemia Martins de Lima
  • Manuela Polydoro
  • José Cláudio Fonseca Moreira
  • Nadja Schroder
  • Felipe Dal-Pizzol
Original Paper

DOI: 10.1007/s11064-006-9249-x

Cite this article as:
Budni, P., de Lima, M.N.M., Polydoro, M. et al. Neurochem Res (2007) 32: 965. doi:10.1007/s11064-006-9249-x

Abstract

Increased levels of iron in specific brain regions have been reported in neurodegenerative disorders. It has been postulated that iron exerts its deleterious effects on the nervous system by inducing oxidative damage. In a previous study, we have shown that iron administered during a particular period of the neonatal life induces oxidative damage in brain regions in adult rats. The aim of the present study was to evaluate the possible protective effect of selegiline, a monoamino-oxidase B (MAO-B) inhibitor used in pharmacotherapy of Parkinson’s disease, against iron-induced oxidative stress in the brain. Results have shown that selegiline (1.0 and 10.0 mg/kg), when administered early in life was able to protect the substantia nigra as well as the hippocampus against iron-induced oxidative stress, without affecting striatum. When selegiline (10.0 mg/kg) was administered in the adult life to iron-treated rats, oxidative stress was reduced only in the substantia nigra.

Keywords

Oxidative stressIronSelegilineSubstantia nigraHippocampusNeuroprotection

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Patrícia Budni
    • 1
    • 2
  • Maria Noemia Martins de Lima
    • 3
  • Manuela Polydoro
    • 4
  • José Cláudio Fonseca Moreira
    • 4
  • Nadja Schroder
    • 3
  • Felipe Dal-Pizzol
    • 1
    • 5
  1. 1.Laboratório de Fisiopatologia ExperimentalUniversidade do Extremo Sul CatarinenseCriciumaBrazil
  2. 2.Programa de Pós-graduação em Ciências AmbientaisUniversidade do Extremo Sul CatarinenseCriciumaBrazil
  3. 3.Programa de Pós-graduação em Gerontologia Biomédica, Departamento de Ciências Fisiológicas, Faculdade de BiociênciasPontificia Universidade Católica do Rio Grande do SulPorto AlegreBrazil
  4. 4.Centro de Estudos em Estresse Oxidativo, Departamento de BioquímicaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  5. 5.Programa de Pós-graduação de Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciumaBrazil