Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination
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- Halder, R.C., Jahng, A., Maricic, I. et al. Neurochem Res (2007) 32: 257. doi:10.1007/s11064-006-9145-4
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Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis.