Neurochemical Research

, Volume 32, Issue 2, pp 257–262

Mini Review: Immune Response to Myelin-Derived Sulfatide and CNS-Demyelination

  • Ramesh C. Halder
  • A. Jahng
  • I. Maricic
  • Vipin Kumar
Review Article

DOI: 10.1007/s11064-006-9145-4

Cite this article as:
Halder, R.C., Jahng, A., Maricic, I. et al. Neurochem Res (2007) 32: 257. doi:10.1007/s11064-006-9145-4

Abstract

Here we briefly review our understanding of the immune response to myelin-derived glycolipids during an inflammatory autoimmune response in the central nervous system (CNS). We focus primarily on the recognition of the self-glycolipid sulfatide by a distinct population of non-invariant NK T cells. The results of studies we have obtained so far in investigating the presentation of sulfatide by CNS-resident cells including microglia and their interactions with T cells indicate that this pathway might be successfully targeted for the treatment of autoimmune demyelination in multiple sclerosis.

Keywords

MyelinSulfatideCentral nervous systemDemyelinationCD1GlycolipidsMicrogliaMultiple sclerosisEAE

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Ramesh C. Halder
    • 1
  • A. Jahng
    • 1
  • I. Maricic
    • 1
  • Vipin Kumar
    • 1
  1. 1.Laboratory of Autoimmunity Torrey Pines Institute for Molecular StudiesSan DiegoUSA