Neurochemical Research

, Volume 32, Issue 4, pp 555–567

Systemic and Brain Metabolic Dysfunction as a New Paradigm for Approaching Alzheimer’s Dementia

  • Vincenzo Giordano
  • Gianfranco Peluso
  • Maurizio Iannuccelli
  • Paola Benatti
  • Raffaella Nicolai
  • Menotti Calvani
ORIGINAL PAPER

DOI: 10.1007/s11064-006-9125-8

Cite this article as:
Giordano, V., Peluso, G., Iannuccelli, M. et al. Neurochem Res (2007) 32: 555. doi:10.1007/s11064-006-9125-8

Abstract

Since its definition Alzheimer’s disease has been at the centre of consideration for neurologists, psychiatrists, and pathologists. With John P. Blass it has been disclosed a different approach Alzheimer’s disease neurodegeneration understanding not only by the means of neurochemistry but also biochemistry opening new scenarios in the direction of a metabolic system degeneration. Nowadays, the understanding of the role of cholesterol, insulin, and adipokines among the others in Alzheimer’s disease etiopathogenesis is clarifying approaches valuable not only in preventing the disease but also for its therapy.

Keywords

Alzheimer’s disease Cholesterol Insulin Leptin Ghrelin Adiponectin 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Vincenzo Giordano
    • 1
  • Gianfranco Peluso
    • 2
  • Maurizio Iannuccelli
    • 1
  • Paola Benatti
    • 1
  • Raffaella Nicolai
    • 1
  • Menotti Calvani
    • 1
  1. 1.Scientific DepartmentSigma-TauPomezia, RomeItaly
  2. 2.Institute of Biochemistry of ProteinsNaplesItaly

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