Neurochemical Research

, Volume 31, Issue 8, pp 1079–1083

C677T Methylentetrahydrofulate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Patients with Alzheimer’s Disease in Iranian Population

  • Mohammad Reza Keikhaee
  • Susan Bany Hashemi
  • Hossein Najmabadi
  • Maryam Noroozian
Original Paper

DOI: 10.1007/s11064-006-9119-6

Cite this article as:
Keikhaee, M.R., Hashemi, S.B., Najmabadi, H. et al. Neurochem Res (2006) 31: 1079. doi:10.1007/s11064-006-9119-6

Abstract

In recent years numerous data suggest that vascular risk factors may be play a role in Alzheimer’s disease (AD). To determine the association of AD with methylentetrahydrofulate reductase (MTHFR) and angiotensin converting enzyme (ACE) as two main vascular risk factors, we examined MTHFR C677T and ACE insertion/deletion (I/D) gene polymorphism in 117 late-onset AD cases and 125 controls. We found no difference in ACE I/D genotype distribution between AD cases and control (P > 0.05) but there was a significant association between AD and the common MTHFR polymorphism C677T. The T allele conferred an increased risk of AD compared to carrying a C allele (P = 0.001, OR = 1.97, 95% CI: 1.3–2.09). Our result suggests a significant increase in risk of AD in cases with the MTHFR T allele, atleast in the Iranian population.

Keywords

Alzheimer’s disease (AD) MTHFR ACE Risk factor 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Mohammad Reza Keikhaee
    • 1
  • Susan Bany Hashemi
    • 1
  • Hossein Najmabadi
    • 1
  • Maryam Noroozian
    • 2
  1. 1.Genetics Research CenterSocial Welfare and Rehabilitation Sciences UniversityTehranIran
  2. 2.Memory and Behavioral Neurology Department, Psychiatry and Psychology Research CenterTehran University of Medical SciencesTehranIran

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