Neurochemical Research

, Volume 30, Issue 11, pp 1365–1367

Is the Platelet Serotonin Transporter Different in Venous vs. Arterial Blood?

  • Emiliano Villa
  • Claudio Albano
  • Andrea Cappelli
  • Emilio Favale
  • Emilia Fugassa
  • Ezio Gerdoni
  • Simona Scarrone
  • Aroldo Cupello
Article

DOI: 10.1007/s11064-005-8342-x

Cite this article as:
Villa, E., Albano, C., Cappelli, A. et al. Neurochem Res (2005) 30: 1365. doi:10.1007/s11064-005-8342-x

Abstract

The binding of labelled paroxetine to the serotonin transporter (SERT) of platelet membranes has been studied in both venous and mixed venous/arterial blood of the rat. In addition, we studied the inhibition of paroxetine binding to SERT by quipazine and N-methyl-quipazine (NMQ). The results indicate differences in affinity for the two test drugs, quipazine and NMQ, in venous vs. mixed venous/arterial blood. This suggests different post-translational modifications of SERT in platelets of arterial vs. venous blood.

Key words

Arterial bloodplateletspostranslational modificationsSERTvenous blood

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Emiliano Villa
    • 1
  • Claudio Albano
    • 2
  • Andrea Cappelli
    • 3
  • Emilio Favale
    • 2
  • Emilia Fugassa
    • 4
  • Ezio Gerdoni
    • 2
  • Simona Scarrone
    • 1
  • Aroldo Cupello
    • 1
  1. 1.Molecular Physiology and Bioimaging Institute, CNR, Sezione di GenovaGenovaItaly
  2. 2.Department of Neuroscience, Ophtalmology and GeneticsFaculty of Medicine, University of GenovaItaly
  3. 3.Pharmacological, Chemical and Technological Department and European Research Centre for Drug Discovery and DevelopmentUniversity of SienaItaly
  4. 4.Department of BiologyFaculty of Science, University of GenovaItaly