Neurochemical Research

, Volume 30, Issue 4, pp 425–428

Decrease of Serotonin Transporters in Blood Platelets after Epileptic Seizures

  • Aroldo Cupello
  • Emilio Favale
  • Daniela Audenino
  • Simona Scarrone
  • Stefania Gastaldi
  • Claudio Albano
Article

DOI: 10.1007/s11064-005-2676-2

Cite this article as:
Cupello, A., Favale, E., Audenino, D. et al. Neurochem Res (2005) 30: 425. doi:10.1007/s11064-005-2676-2
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Abstract

Serotonin transporter (SERT) was studied by [3H]-paroxetine binding in blood platelets from controls and epileptic patients with generalized convulsive seizures. The average KD and BMax were not different in the two cases. However, a significant decrease was found in the serotonin transporter density in the platelet membranes from patients having undergone an epileptic seizure less than 4 days before. This circumstance may indicate a homeostatic reaction to the epileptic attack.

Keywords

Epilepsy serotonin blood platelets SERT paroxetine binding 

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Aroldo Cupello
    • 1
  • Emilio Favale
    • 2
  • Daniela Audenino
    • 2
  • Simona Scarrone
    • 1
  • Stefania Gastaldi
    • 2
  • Claudio Albano
    • 2
  1. 1.Istituto di Bioimmagini e Fisiologia MolecolareCNR Sezione di GenovaItaly
  2. 2.Dipartimento di Neuroscienze, Oftalmologia e Genetica, Facoltà di MedicinaUniversità di GenovaItaly
  3. 3.IBFMCNR, Sezione di GenovaGenovaItaly