Journal of Neuro-Oncology

, Volume 114, Issue 1, pp 111–116

Prospective evaluation of health-related quality of life in patients with glioblastoma multiforme treated on a phase II trial of hypofractionated IMRT with temozolomide

  • Krishna Reddy
  • Laurie E. Gaspar
  • Brian D. Kavanagh
  • Allen Waziri
  • Denise M. Damek
  • Douglas Ney
  • Kevin O. Lillehei
  • Changhu Chen
Clinical Study

DOI: 10.1007/s11060-013-1159-6

Cite this article as:
Reddy, K., Gaspar, L.E., Kavanagh, B.D. et al. J Neurooncol (2013) 114: 111. doi:10.1007/s11060-013-1159-6

Abstract

To report health-related quality of life (HRQOL) in glioblastoma (GBM) patients treated on a phase II trial of hypofractionated intensity-modulated radiotherapy (hypo-IMRT) with temozolomide (TMZ). GBM patients received postoperative hypo-IMRT to 60 Gy in 10 fractions with TMZ. HRQOL was assessed using the EORTC quality of life questionnaire core-30 and the EORTC brain cancer module, performed at baseline, RT completion, 1 mo post-RT, and every 3 mos thereafter. Changes from baseline were calculated for each specific HRQOL scale. A ≥ 10 point change in any HRQOL scale from the mean baseline score was significant. 24 patients were treated. Compliance with HRQOL assessments at baseline, RT completion, and 1, 3, 6, 9, and 12 mos post-RT was 100, 96, 92, 79, 70, 68 and 53 %, respectively. Up to 12 mos post-RT, no significant changes were seen in global health status, physical functioning, role functioning, emotional functioning, fatigue, nausea, vision, headache or seizure. Significant improvement was seen in insomnia, future uncertainty, motor dysfunction and drowsiness. Significant worsening was observed in cognitive functioning, social functioning, appetite loss and communication deficit. 60 Gy hypo-IMRT in 6-Gy fractions with TMZ does not appear to negatively impact overall HRQOL.

Keywords

High-grade glioma Glioblastoma Hypofractionation Quality of life 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Krishna Reddy
    • 1
  • Laurie E. Gaspar
    • 1
  • Brian D. Kavanagh
    • 1
  • Allen Waziri
    • 2
  • Denise M. Damek
    • 3
  • Douglas Ney
    • 3
  • Kevin O. Lillehei
    • 2
  • Changhu Chen
    • 1
    • 4
  1. 1.Departments of Radiation OncologyUniversity of Colorado School of MedicineAuroraUSA
  2. 2.Department of NeurosurgeryUniversity of Colorado School of MedicineAuroraUSA
  3. 3.Department of NeurologyUniversity of Colorado School of MedicineAuroraUSA
  4. 4.Department of Radiation OncologyUniversity of ToledoToledoUSA