Journal of Neuro-Oncology

, Volume 109, Issue 1, pp 167–175

Waiting times before initiation of radiotherapy might not affect outcomes for patients with glioblastoma: a French retrospective analysis of patients treated in the era of concomitant temozolomide and radiotherapy

  • Georges Noel
  • Aymeri Huchet
  • Loic Feuvret
  • Jean Philippe Maire
  • Pierre Verrelle
  • Emilie Le Rhun
  • Maud Aumont
  • François Thillays
  • Marie Pierre Sunyach
  • Chantal Henzen
  • Fernand Missohou
  • Renaud de Crevoisier
  • Pierre Yves Bondiau
  • Philippe Collin
  • Xavier Durando
  • Gilles Truc
  • Christine Kerr
  • Valérie Bernier
  • Jean-Baptiste Clavier
  • David Atlani
  • Anne D’Hombres
  • Sandrine Vinchon-Petit
  • Jean Léon Lagrange
  • Luc Taillandier
Clinical Study

DOI: 10.1007/s11060-012-0883-7

Cite this article as:
Noel, G., Huchet, A., Feuvret, L. et al. J Neurooncol (2012) 109: 167. doi:10.1007/s11060-012-0883-7

Abstract

Purpose of this study was to determine the effect of waiting time for radiotherapy on overall survival of patients with glioblastoma treated in the EORTC-NCIC trial at 18 centers in France. A total of 400 adult patients with glioblastoma who were treated between January 1, 2006 and December 31, 2006 were included. There were 282 patients with “minimum criteria” according to the EORTC-NCIC trial: (i) concurrent chemotherapy with temozolomide; and (ii) age between 18 and 70 years old. Among these patients, 229 were treated with adjuvant temozolomide and were classified as “maximal criteria”. One-hundred and eighteen patients were in the “without minimal criteria” group. Waiting time from the first symptom (FS-RT), pathology diagnosis (P-RT), multidisciplinary meeting (MM-RT), surgery (S-RT), and CT scan for delineation (CT-RT) until the start of radiotherapy were recorded. Median follow-up for all patients was 327 days. Overall, median FS-RT, P-RT, MM-RT, CT-RT, and S-RT times were 77, 36, 32, 12, and 41 days, respectively. Median, and 12 and 24-month overall survival were 409 days, and 56.3 ± 2.1 % and 27.6 ± 2.6 %, respectively. Univariate analysis failed to reveal a difference in survival, irrespective of the delay. In multivariate analysis, independent favorable prognostic factors for overall survival were age (p ≤ 0.0001) and type of surgery (p = 0.0006). In this large series treated during the EORTC-NCIC protocol period, waiting time until radiotherapy did not seem to affect patient outcome.

Keywords

Glioblastoma multiforme Waiting time Radiotherapy Temozolomide Survival 

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Georges Noel
    • 1
  • Aymeri Huchet
    • 2
  • Loic Feuvret
    • 3
  • Jean Philippe Maire
    • 2
  • Pierre Verrelle
    • 4
  • Emilie Le Rhun
    • 5
  • Maud Aumont
    • 6
  • François Thillays
    • 6
  • Marie Pierre Sunyach
    • 7
  • Chantal Henzen
    • 8
  • Fernand Missohou
    • 8
  • Renaud de Crevoisier
    • 9
  • Pierre Yves Bondiau
    • 10
  • Philippe Collin
    • 11
  • Xavier Durando
    • 4
  • Gilles Truc
    • 12
  • Christine Kerr
    • 13
  • Valérie Bernier
    • 14
  • Jean-Baptiste Clavier
    • 1
  • David Atlani
    • 15
  • Anne D’Hombres
    • 16
  • Sandrine Vinchon-Petit
    • 17
  • Jean Léon Lagrange
    • 18
  • Luc Taillandier
    • 19
  1. 1.CLCC Paul Strauss3 Rue de la Porte de l’HôpitalStrasbourg CedexFrance
  2. 2.CHU de BordeauxBordeauxFrance
  3. 3.CHU Pitié-Salpêtrière47-83, Bd de l’HôpitalParis Cedex 13France
  4. 4.CLCC Jean PerrinClermont-Ferrand Cedex 01France
  5. 5.CLCC Oscar LambretLille CedexFrance
  6. 6.CLCC René GauducheauNantes Saint-Herblain CedexFrance
  7. 7.CLCC Léon BérardLyon Cedex 08France
  8. 8.CLCC de Haute Normandie Henri BecquerelRouenFrance
  9. 9.CLCC Eugène MarquisRennes CedexFrance
  10. 10.CLCC Antoine LacassagneNiceFrance
  11. 11.Clinique de CourlancyReimsFrance
  12. 12.CLCC Georges-François LeclercDijon CedexFrance
  13. 13.CLCC Val d’Aurelle-Paul LamarqueMontpellier Cedex 5France
  14. 14.CLCC Alexis VautrinVandoeuvre-Lès-Nancy CedexFrance
  15. 15.CHR PasteurColmarFrance
  16. 16.CHU Lyon SudPierre-Bénite CedexFrance
  17. 17.CLCC Paul PapinAngers Cedex 9France
  18. 18.CHU Henri MondorCréteilFrance
  19. 19.Service de Neurologie CHU BraboisNancyFrance

Personalised recommendations