Journal of Neuro-Oncology

, Volume 107, Issue 3, pp 457–462

Chlorotoxin-conjugated nanoparticles as potential glioma-targeted drugs

Topic Review

DOI: 10.1007/s11060-011-0763-6

Cite this article as:
Fu, Y., An, N., Li, K. et al. J Neurooncol (2012) 107: 457. doi:10.1007/s11060-011-0763-6

Abstract

Development of glioma-specific nanoparticles has been an area of intense research over the past several years. Iron oxide, multifunctional superparamagnetic, and NaYF4:Yb,rare-earth upconversion nanoparticles, conjugated with chlorotoxin (CTX, a key toxin in scorpion venom which has been shown to bind specifically to glioma cell surface as a specific chloride channel and matrix metalloproteinase-2 blocker), exhibit high affinity for glioma and direct tumor visualization. We review the latest improvements of CTX-modified nanoparticle platforms which might enable development of more effective therapeutic agents in clinical treatment of glioma.

Keywords

Chlorotoxin (CTX) Nanoparticles Glioma 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Yuejun Fu
    • 1
  • Na An
    • 1
  • Ke Li
    • 2
  • Yali Zheng
    • 1
  • Aihua Liang
    • 1
  1. 1.Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationInstitute of Biotechnology, Shanxi UniversityTaiyuanPeople’s Republic of China
  2. 2.Zhejiang Entry–Exit Inspection and Quarantine BureauHangzhouPeople’s Republic of China

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