Journal of Neuro-Oncology

, Volume 107, Issue 1, pp 1–12

Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights

  • Kimberly Ng
  • Ryan Kim
  • Santosh Kesari
  • Bob Carter
  • Clark C. Chen
Topic Review

DOI: 10.1007/s11060-011-0714-2

Cite this article as:
Ng, K., Kim, R., Kesari, S. et al. J Neurooncol (2012) 107: 1. doi:10.1007/s11060-011-0714-2

Abstract

With advances in genomic profiling and sequencing technology, we are beginning to understand the landscape of the genetic events that accumulated during the neoplastic process. The insights gleamed from these genomic profiling studies with regards to glioblastoma etiology has been particularly satisfying because it cemented the clinical pertinence of major concepts in cancer biology—concepts developed over the past three decades. This article will review how the glioblastoma genomic data set serves as an illustrative platform for the concepts put forward by Hanahan and Weinberg on the cancer phenotype. The picture emerging suggests that most glioblastomas evolve along a multitude of pathways rather than a single defined pathway. In this context, the article will further provide a discussion of the subtypes of glioblastoma as they relate to key principles of developmental neurobiology.

Keywords

Glioblastoma TCGA Genomics RTK RB p53 IDH1 Telomerase Angiogenesis Invasion Subtype Cancer 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Kimberly Ng
    • 1
  • Ryan Kim
    • 2
  • Santosh Kesari
    • 2
  • Bob Carter
    • 3
  • Clark C. Chen
    • 1
    • 3
    • 4
  1. 1.Department of Radiation OncologyDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of NeurologyMoores UCSD Cancer Center, University of California, San DiegoLa JollaUSA
  3. 3.Center for Theoretic and Applied Neuro-OncologyUniversity of California, San DiegoLa JollaUSA
  4. 4.Division of NeurosurgeryUniversity of California, San DiegoLa JollaUSA