Journal of Neuro-Oncology

, Volume 106, Issue 3, pp 561–569

R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro

Authors

    • Department of Neurosurgery, Huntsman Cancer InstituteUniversity of Utah School of Medicine
    • Department of Neurological Surgery, Neurological Institute of New Jersey, New Jersey Medical SchoolUniversity of Medicine and Dentistry of New Jersey
  • Smruti K. Patel
    • Department of Neurological Surgery, Neurological Institute of New Jersey, New Jersey Medical SchoolUniversity of Medicine and Dentistry of New Jersey
  • David L. Gillespie
    • Department of Neurosurgery, Huntsman Cancer InstituteUniversity of Utah School of Medicine
  • Kum Whang
    • Department of Neurosurgery, Huntsman Cancer InstituteUniversity of Utah School of Medicine
    • Department of NeurosurgeryWonju College of Medicine, Yonsei University
  • William T. Couldwell
    • Department of Neurosurgery, Huntsman Cancer InstituteUniversity of Utah School of Medicine
Laboratory Investigation - Human/Animal Tissue

DOI: 10.1007/s11060-011-0712-4

Cite this article as:
Liu, J.K., Patel, S.K., Gillespie, D.L. et al. J Neurooncol (2012) 106: 561. doi:10.1007/s11060-011-0712-4

Abstract

R-flurbiprofen, a nonsteroidal anti-inflammatory drug derivative, has been shown to inhibit colonic adenoma formation in mice. We investigated the effects of R-flurbiprofen on cell proliferation and apoptosis in pituitary adenoma cell lines. GH4C1 rat pituitary cell line cultures and low-passage human primary pituitary cell cultures were treated with varying concentrations of R-flurbiprofen (0.1–1.0 mM). R-flurbiprofen inhibited cell proliferation in a dose-dependent fashion. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay and chromatin condensation/dead cell apoptosis assay demonstrated induction of apoptosis at higher concentrations of R-flurbiprofen. R-flurbiprofen decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. This may be a potential therapy in the management of pituitary adenoma.

Keywords

Nonsteroidal anti-inflammatory drugCyclooxygenase-2Pituitary adenomaApoptosisR-flurbiprofen

Copyright information

© Springer Science+Business Media, LLC. 2011