Journal of Neuro-Oncology

, Volume 106, Issue 3, pp 561–569

R-flurbiprofen, a novel nonsteroidal anti-inflammatory drug, decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro

  • James K. Liu
  • Smruti K. Patel
  • David L. Gillespie
  • Kum Whang
  • William T. Couldwell
Laboratory Investigation - Human/Animal Tissue

DOI: 10.1007/s11060-011-0712-4

Cite this article as:
Liu, J.K., Patel, S.K., Gillespie, D.L. et al. J Neurooncol (2012) 106: 561. doi:10.1007/s11060-011-0712-4

Abstract

R-flurbiprofen, a nonsteroidal anti-inflammatory drug derivative, has been shown to inhibit colonic adenoma formation in mice. We investigated the effects of R-flurbiprofen on cell proliferation and apoptosis in pituitary adenoma cell lines. GH4C1 rat pituitary cell line cultures and low-passage human primary pituitary cell cultures were treated with varying concentrations of R-flurbiprofen (0.1–1.0 mM). R-flurbiprofen inhibited cell proliferation in a dose-dependent fashion. A terminal deoxynucleotidyl transferase dUTP nick end labeling assay and chromatin condensation/dead cell apoptosis assay demonstrated induction of apoptosis at higher concentrations of R-flurbiprofen. R-flurbiprofen decreases cell proliferation and induces apoptosis in pituitary adenoma cells in vitro. This may be a potential therapy in the management of pituitary adenoma.

Keywords

Nonsteroidal anti-inflammatory drugCyclooxygenase-2Pituitary adenomaApoptosisR-flurbiprofen

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • James K. Liu
    • 1
    • 2
  • Smruti K. Patel
    • 2
  • David L. Gillespie
    • 1
  • Kum Whang
    • 1
    • 3
  • William T. Couldwell
    • 1
  1. 1.Department of Neurosurgery, Huntsman Cancer InstituteUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Department of Neurological Surgery, Neurological Institute of New Jersey, New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA
  3. 3.Department of NeurosurgeryWonju College of Medicine, Yonsei UniversityGangwonKorea