Journal of Neuro-Oncology

, Volume 106, Issue 2, pp 235–242

Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas

  • Jason A. Ellis
  • Peter Canoll
  • Paul C. McCormickII
  • Neil A. Feldstein
  • Richard C. Anderson
  • Peter D. Angevine
  • Michael G. Kaiser
  • Paul C. McCormick
  • Jeffrey N. Bruce
  • Alfred T. Ogden
Laboratory Investigation - Human/Animal Tissue

DOI: 10.1007/s11060-011-0666-6

Cite this article as:
Ellis, J.A., Canoll, P., McCormick, P.C. et al. J Neurooncol (2012) 106: 235. doi:10.1007/s11060-011-0666-6

Abstract

Abnormal signaling through the platelet-derived growth factor receptor (PDGFR) has been proposed as a possible mechanism of spinal cord glioma initiation and progression. However, the extent of PDGFR expression in human spinal cord gliomas remains unknown. In this study we perform immunohistochemical analysis of PDGFRα expression in a series of 33 primary intramedullary spinal cord gliomas of different types and grades. PDGFRα was seen to be expressed in a significant subset of these tumors across all major glioma types including ependymoma, oligodendroglioma, pilocytic astrocytoma, astrocytoma, and glioblastoma. These results support the hypothesis that growth factor signaling through the PDGFR may be important for the development of at least a subset of human spinal cord gliomas. Further studies investigating the prognostic significance of PDGFR expression as well as the role of PDGF signaling on the development of intramedullary spinal cord gliomas are warranted.

Keywords

Astrocytoma Ependymoma Glioblastoma multiforme Glioma Intramedullary Oligodendroglioma Pilocytic Spinal cord Tumor 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Jason A. Ellis
    • 1
  • Peter Canoll
    • 2
  • Paul C. McCormickII
    • 1
  • Neil A. Feldstein
    • 1
  • Richard C. Anderson
    • 1
  • Peter D. Angevine
    • 1
  • Michael G. Kaiser
    • 1
  • Paul C. McCormick
    • 1
  • Jeffrey N. Bruce
    • 1
  • Alfred T. Ogden
    • 1
  1. 1.Department of Neurological SurgeryNeurological Institute of New York, Columbia University Medical CenterNew YorkUSA
  2. 2.Department of Pathology and Cell BiologyColumbia University Medical CenterNew YorkUSA

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