Journal of Neuro-Oncology

, Volume 105, Issue 3, pp 451–466

The roles of viruses in brain tumor initiation and oncomodulation

Authors

  • Alexander Kofman
    • Department of MicrobiologyUniversity of Virginia
  • Lucasz Marcinkiewicz
    • Department of MicrobiologyUniversity of Virginia
  • Evan Dupart
    • Department of MicrobiologyUniversity of Virginia
  • Anton Lyshchev
    • St. Petersburg State Department of HealthLaboratory of Molecular Genetics, Hospital #31
  • Boris Martynov
    • S.M.Kirov Medical Academy
  • Anatolii Ryndin
    • Clinical Diagnostic Center
  • Elena Kotelevskaya
    • St. Petersburg State Department of HealthLaboratory of Molecular Genetics, Hospital #31
  • Jay Brown
    • Department of MicrobiologyUniversity of Virginia
  • David Schiff
    • Department of Cancer CenterUniversity of Virginia
    • Department of MicrobiologyUniversity of Virginia
    • Department of Cancer CenterUniversity of Virginia
Topic Review

DOI: 10.1007/s11060-011-0658-6

Cite this article as:
Kofman, A., Marcinkiewicz, L., Dupart, E. et al. J Neurooncol (2011) 105: 451. doi:10.1007/s11060-011-0658-6

Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

Keywords

GliomasBrain tumorsVirusesHerpesvirusesRetrovirusesOncomodulationProgenitorsStem cells

Copyright information

© Springer Science+Business Media, LLC. 2011