Journal of Neuro-Oncology

, Volume 105, Issue 3, pp 451–466

The roles of viruses in brain tumor initiation and oncomodulation

  • Alexander Kofman
  • Lucasz Marcinkiewicz
  • Evan Dupart
  • Anton Lyshchev
  • Boris Martynov
  • Anatolii Ryndin
  • Elena Kotelevskaya
  • Jay Brown
  • David Schiff
  • Roger Abounader
Topic Review

DOI: 10.1007/s11060-011-0658-6

Cite this article as:
Kofman, A., Marcinkiewicz, L., Dupart, E. et al. J Neurooncol (2011) 105: 451. doi:10.1007/s11060-011-0658-6

Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

Keywords

GliomasBrain tumorsVirusesHerpesvirusesRetrovirusesOncomodulationProgenitorsStem cells

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Alexander Kofman
    • 1
  • Lucasz Marcinkiewicz
    • 1
  • Evan Dupart
    • 1
  • Anton Lyshchev
    • 3
  • Boris Martynov
    • 4
  • Anatolii Ryndin
    • 5
  • Elena Kotelevskaya
    • 3
  • Jay Brown
    • 1
  • David Schiff
    • 2
  • Roger Abounader
    • 1
    • 2
  1. 1.Department of MicrobiologyUniversity of VirginiaCharlottesvilleUSA
  2. 2.Department of Cancer CenterUniversity of VirginiaCharlottesvilleUSA
  3. 3.St. Petersburg State Department of HealthLaboratory of Molecular Genetics, Hospital #31St. PetersburgRussia
  4. 4.S.M.Kirov Medical AcademySt. PetersburgRussia
  5. 5.Clinical Diagnostic CenterSt. PetersburgRussia