Journal of Neuro-Oncology

, Volume 106, Issue 1, pp 185–200

Chronic lymphocytic leukemia with central nervous system involvement: report of two cases with a comprehensive literature review

  • Alan A. Moazzam
  • Jan Drappatz
  • Ryan Y. Kim
  • Santosh Kesari
Case Report

DOI: 10.1007/s11060-011-0636-z

Cite this article as:
Moazzam, A.A., Drappatz, J., Kim, R.Y. et al. J Neurooncol (2012) 106: 185. doi:10.1007/s11060-011-0636-z

Abstract

Central nervous system (CNS) involvement is a rare complication of chronic lymphocytic leukemia (CLL) with varied outcomes. We contribute two additional cases of CLL with CNS involvement. The clinical course and response to treatment are described. All 78 previously reported cases of CLL with CNS involvement are presented in this comprehensive review of the literature. CNS involvement of CLL is a rare complication that does not seem to correlate with any evident risk factors. Resolution of CNS symptoms can often be accomplished with intrathecal chemotherapy or irradiation. Early detection and treatment may result in better outcomes in this rare complication.

Keywords

LeukemiaChronic lymphocytic leukemiaCNSLeptomeningeal metastasesBrain

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Alan A. Moazzam
    • 1
  • Jan Drappatz
    • 2
  • Ryan Y. Kim
    • 1
  • Santosh Kesari
    • 1
  1. 1.Department of Neurosciences, Moores UCSD Cancer CenterUniversity of California at San DiegoLa JollaUSA
  2. 2.Department of NeurologyBrigham and Women’s HospitalBostonUSA