Journal of Neuro-Oncology

, Volume 105, Issue 2, pp 233–239

Characterization of bevacizumab dose response relationship in U87 brain tumors using magnetic resonance imaging measures of enhancing tumor volume and relative cerebral blood volume

  • Kimberly R. Pechman
  • Deborah L. Donohoe
  • Devyani P. Bedekar
  • Shekar N. Kurpad
  • Raymond G. Hoffmann
  • Kathleen M. Schmainda
Laboratory Investigation - Human/Animal Tissue

DOI: 10.1007/s11060-011-0591-8

Cite this article as:
Pechman, K.R., Donohoe, D.L., Bedekar, D.P. et al. J Neurooncol (2011) 105: 233. doi:10.1007/s11060-011-0591-8

Abstract

Despite the early promising results with the anti-angiogenic agent, bevacizumab, to prolong time to progression in patients with brain tumors, the optimal dose and drug combinations have not yet been defined. The purpose of this study was to characterize the bevacizumab dose–response relationship for brain tumors by measuring the contrast-agent enhanced tumor volumes and relative cerebral blood volume (rCBV) using dynamic susceptibility contrast (DSC) imaging. The studies, performed in the U87 brain tumor model using doses of bevacizumab ranging from 0 to 10 mg/kg, demonstrate that tumor growth and vascularity are inhibited at all doses used, compared to untreated controls. However, only the maximum dose showed a statistically significant difference in growth rate. Conversely tumor vascularity, as measured with rCBV, was inhibited equally well for all doses used with no clear indication that higher doses are more effective.

Keywords

Glioblastoma Bevacizumab MRI rCBV Dose–response 

Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Kimberly R. Pechman
    • 1
    • 2
  • Deborah L. Donohoe
    • 1
    • 3
  • Devyani P. Bedekar
    • 1
    • 3
  • Shekar N. Kurpad
    • 1
    • 2
    • 4
  • Raymond G. Hoffmann
    • 5
  • Kathleen M. Schmainda
    • 1
    • 3
    • 6
  1. 1.Translational Brain Tumor ProgramMedical College of WisconsinMilwaukeeUSA
  2. 2.Department of NeurosurgeryMedical College of WisconsinMilwaukeeUSA
  3. 3.Department of RadiologyMedical College of WisconsinMilwaukeeUSA
  4. 4.Clement J Zablocki VA Medical CenterMilwaukeeUSA
  5. 5.Department of PediatricsMedical College of WisconsinMilwaukeeUSA
  6. 6.Department of BiophysicsMedical College of WisconsinMilwaukeeUSA

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