Journal of Neuro-Oncology

, Volume 103, Issue 3, pp 397–408

Understanding the role of tumor stem cells in glioblastoma multiforme: a review article

  • Aalya Fatoo
  • Michael J. Nanaszko
  • Baxter B. Allen
  • Christina L. Mok
  • Elena N. Bukanova
  • Robel Beyene
  • Jennifer A. Moliterno
  • John A. Boockvar
Topic Review

DOI: 10.1007/s11060-010-0406-3

Cite this article as:
Fatoo, A., Nanaszko, M.J., Allen, B.B. et al. J Neurooncol (2011) 103: 397. doi:10.1007/s11060-010-0406-3
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Abstract

It has been hypothesized that cancer stem cells (CSC) may account for the pathogenesis underlying various tumors, including GBM. Markers of these CSCs can be potentially used as therapeutic targets. In this review, we discuss the most recent information regarding CSCs, their molecular biology and their potential role in GBM.

Keywords

Neural stem cellsGliomaBrain tumors

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Aalya Fatoo
    • 1
  • Michael J. Nanaszko
    • 1
  • Baxter B. Allen
    • 1
  • Christina L. Mok
    • 1
  • Elena N. Bukanova
    • 1
  • Robel Beyene
    • 1
  • Jennifer A. Moliterno
    • 1
    • 2
  • John A. Boockvar
    • 1
  1. 1.Neurosurgical Laboratory for Translational Stem Cell Research, Department of Neurosurgery, Weill Cornell Brain Tumor CenterWeill Cornell Medical College of Cornell UniversityNew YorkUSA
  2. 2.Department of NeurosurgeryYale University School of MedicineNew HavenUSA