Case Report

Journal of Neuro-Oncology

, Volume 101, Issue 1, pp 141-143

First online:

Anal cancer with cerebral metastasis: a case report

  • Anand I. RughaniAffiliated withDivision of Neurosurgery, University of Vermont Email author 
  • , Chih LinAffiliated withCollege of Medicine, University of Vermont
  • , Bruce I. TranmerAffiliated withDivision of Neurosurgery, University of Vermont
  • , James T. WilsonAffiliated withMaine Medical Center, Neuroscience Institute

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Carcinoma of the anal canal is a relatively rare cancer with a low propensity for metastasis. A literature review identifies two cases of brain metastases from anal cancer. The authors present the case of a 63-year-old female with poorly differentiated squamous cell carcinoma of the anal canal who presented with a solitary dural-based enhancing lesion of the right parietal area. The patient underwent craniectomy and tumor resection. Histopathology confirmed the cerebral lesion to be a poorly differentiated squamous cell carcinoma, consistent with the known primary tumor of the anal canal. Although exceptionally rare, the presence of a cerebral lesion in a patient with carcinoma of the anal canal should raise the possibility of metastatic disease. Treatment decisions in patients with newly diagnosed dural-based enhancing lesions and known anal cancer should bear in mind the possibility of metastatic disease.


Brain neoplasms Anus neoplasms Neoplasm metastasis