Journal of Neuro-Oncology

, Volume 101, Issue 1, pp 141–143

Anal cancer with cerebral metastasis: a case report


    • Division of NeurosurgeryUniversity of Vermont
  • Chih Lin
    • College of MedicineUniversity of Vermont
  • Bruce I. Tranmer
    • Division of NeurosurgeryUniversity of Vermont
  • James T. Wilson
    • Maine Medical CenterNeuroscience Institute
Case Report

DOI: 10.1007/s11060-010-0218-5

Cite this article as:
Rughani, A.I., Lin, C., Tranmer, B.I. et al. J Neurooncol (2011) 101: 141. doi:10.1007/s11060-010-0218-5


Carcinoma of the anal canal is a relatively rare cancer with a low propensity for metastasis. A literature review identifies two cases of brain metastases from anal cancer. The authors present the case of a 63-year-old female with poorly differentiated squamous cell carcinoma of the anal canal who presented with a solitary dural-based enhancing lesion of the right parietal area. The patient underwent craniectomy and tumor resection. Histopathology confirmed the cerebral lesion to be a poorly differentiated squamous cell carcinoma, consistent with the known primary tumor of the anal canal. Although exceptionally rare, the presence of a cerebral lesion in a patient with carcinoma of the anal canal should raise the possibility of metastatic disease. Treatment decisions in patients with newly diagnosed dural-based enhancing lesions and known anal cancer should bear in mind the possibility of metastatic disease.


Brain neoplasmsAnus neoplasmsNeoplasm metastasis

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© Springer Science+Business Media, LLC. 2010