Journal of Neuro-Oncology

, Volume 94, Issue 2, pp 169–172

No association of (−131C→G) variant of CHI3L1 gene with risk of glioblastoma and prognosis

Authors

  • Blandine Boisselier
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
  • Yannick Marie
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
  • Soufiane El Hallani
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
  • Gentian Kaloshi
    • Service de Neurologie MazarinGroupe Hospitalier Pitié-Salpêtrière
  • Anton Iershov
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Institute of Molecular Biology and GeneticsNASU
  • Vadym Kavsan
    • Institute of Molecular Biology and GeneticsNASU
  • Dimitri Psimaras
    • Service de Neurologie MazarinGroupe Hospitalier Pitié-Salpêtrière
  • Joëlle Thillet
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
  • Khe Hoang-Xuan
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
    • Service de Neurologie MazarinGroupe Hospitalier Pitié-Salpêtrière
  • Jean-Yves Delattre
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
    • Service de Neurologie MazarinGroupe Hospitalier Pitié-Salpêtrière
    • INSERM, U711, Biologie des Interactions Neurones & Glie
    • Faculté de MédecineUniversité Pierre et Marie Curie
    • Service de Neurologie MazarinGroupe Hospitalier Pitié-Salpêtrière
Laboratory Investigations - Human/Animal Tissue

DOI: 10.1007/s11060-009-9817-4

Cite this article as:
Boisselier, B., Marie, Y., El Hallani, S. et al. J Neurooncol (2009) 94: 169. doi:10.1007/s11060-009-9817-4

Abstract

Expression of CHI3L1 (YKL-40) has been correlated with prognosis of glioblastoma. The variant allele (−131C→G) of CHI3L1 promoter results in a lower transcription of CHI3L1. Therefore, we tested the hypothesis that the G variant could protect against the risk of gliomas or have a favorable prognostic impact. DNA from 296 glioblastoma patients and 190 controls were genotyped on the −131 allele. Tumor RNA was obtained from 108 patients for CHI3L1 transcript quantification. Neither genotype nor allele distribution differed between patients and controls. There was no significant difference in survival between the CC, CG, and GG patients despite the few GG patients tended to have a longer survival. There was no correlation between genotype and CHI3L1 expression in tumor samples. Taken together our data suggest that the variant allele (−131C→G) of CHI3L1 promoter has no significant impact on survival and is not a prognostic factor for glioblastoma.

Keywords

GlioblastomaCHI3L1PolymorphismPrognosis

Copyright information

© Springer Science+Business Media, LLC. 2009