Journal of Neuro-Oncology

, Volume 94, Issue 1, pp 51–56

Medulloblastoma in children under the age of three years: a retrospective Canadian review

  • Donna L. Johnston
  • Daniel Keene
  • Ute Bartels
  • Anne-Sophie Carret
  • Bruce Crooks
  • David D. Eisenstat
  • Chris Fryer
  • Lucie Lafay-Cousin
  • Valerie Larouche
  • Albert Moghrabi
  • Beverly Wilson
  • Shayna Zelcer
  • Mariana Silva
  • Josee Brossard
  • Eric Bouffet
Clinical Study - Patient Study

DOI: 10.1007/s11060-009-9799-2

Cite this article as:
Johnston, D.L., Keene, D., Bartels, U. et al. J Neurooncol (2009) 94: 51. doi:10.1007/s11060-009-9799-2

Abstract

Children under the age of 3 with medulloblastoma have an inferior survival to older children with this disease. This study reviewed the incidence, characteristics, therapy, and outcome of children less than 36 months of age diagnosed with medulloblastoma from 1990 to 2005 in Canada. Ninety-six cases were identified with a median age at diagnosis of 19.5 months. Forty-seven percent of patients had a complete resection, 25% a 90–95% near complete resection, 20% an incomplete (10–90%) resection, and 3% biopsy only. Therapy consisted of chemotherapy (90%), high dose chemotherapy with stem cell rescue (13%), and radiation therapy (21%). The median survival time was 45 ± 13.82 months. There was no significant difference in survival when comparing patients with <90% resection versus >90% resection, nor when comparing the presence of metastases versus their absence. There was a significant increase in survival time in patients who received radiation therapy compared to those who were not treated with this modality, as well as for those who were over 18 months at diagnosis compared to those under 18 months.

Keywords

MedulloblastomaInfants

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Donna L. Johnston
    • 1
  • Daniel Keene
    • 2
  • Ute Bartels
    • 3
  • Anne-Sophie Carret
    • 4
  • Bruce Crooks
    • 5
  • David D. Eisenstat
    • 6
  • Chris Fryer
    • 7
  • Lucie Lafay-Cousin
    • 8
  • Valerie Larouche
    • 9
  • Albert Moghrabi
    • 10
  • Beverly Wilson
    • 11
  • Shayna Zelcer
    • 12
  • Mariana Silva
    • 13
  • Josee Brossard
    • 14
  • Eric Bouffet
    • 3
  1. 1.Division of OncologyChildren’s Hospital of Eastern OntarioOttawa, OntarioCanada
  2. 2.Division of NeurologyChildren’s Hospital of Eastern OntarioOttawaCanada
  3. 3.Division of OncologyThe Hospital for Sick ChildrenTorontoCanada
  4. 4.Division of OncologyMontreal Children’s HospitalMontrealCanada
  5. 5.Division of OncologyIWKHalifaxCanada
  6. 6.Cancer Care ManitobaWinnipegCanada
  7. 7.Division of OncologyBC Children’s HospitalVancouverCanada
  8. 8.Division of OncologyAlberta Children’s HospitalCalgaryCanada
  9. 9.Division of OncologyCentre Hospitalier Universitaire de QuebecQuebecCanada
  10. 10.Division of OncologySte Justine HospitalMontrealCanada
  11. 11.Division of OncologyStollery Children’s HospitalEdmontonCanada
  12. 12.Division of OncologyChildren’s Hospital of Western OntarioLondonCanada
  13. 13.Division of OncologyKingston General HospitalKingstonCanada
  14. 14.Division of OncologyCentre Hospitalier Universitaire de SherbrookeSherbrookeCanada