Journal of Neuro-Oncology

, 92:233

Rapid growth of primary cerebral fibrosarcoma with conversion to glioblastoma at second recurrence

  • Amos Olufemi Adeleye
  • Yakov Fellig
  • Felix Umansky
  • Yigal Shoshan
Case Report

DOI: 10.1007/s11060-008-9756-5

Cite this article as:
Adeleye, A.O., Fellig, Y., Umansky, F. et al. J Neurooncol (2009) 92: 233. doi:10.1007/s11060-008-9756-5


We present a case of de novo fibrosarcoma in a 43-year-old male, with MRI documented evolution from a 5 mm hyperintense area to 5 cm tumor mass in a 12-month period. The diagnosis of low-grade fibrosarcoma was established by three experienced neuropathologists. The patient underwent gross total resection with adjuvant fractionated conformal radiotherapy. Following first recurrence 3 months later, the patient was reoperated and stereotactic radiosurgery of a residual tumor was performed thereafter. The pathological diagnosis was similar, but with additional extensive radiation effects. Six months later the patient underwent aggressive surgical resection for second recurrence. The pathological diagnosis was WHO grade IV glioblastoma. The etiology of this highly unusual progression from primary mesenchymal neoplasm to high-grade glioma is discussed.


Gliomatous differentiationGliosarcomaPrimary cerebral fibrosarcomaRapid growth



Computerized tomography


Fluid attenuated inversion recovery


Magnetic resonance imaging


Isodose line



Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Amos Olufemi Adeleye
    • 1
    • 2
  • Yakov Fellig
    • 3
  • Felix Umansky
    • 1
  • Yigal Shoshan
    • 1
  1. 1.Department of NeurosurgeryHadassah – Hebrew University Medical CenterJerusalemIsrael
  2. 2.Division of Neurological Surgery, Department of SurgeryCollege of Medicine – University of Ibadan and University College HospitalIbadanNigeria
  3. 3.Department of PathologyHadassah – Hebrew University Medical CenterJerusalemIsrael