Journal of Neuro-Oncology

, Volume 92, Issue 1, pp 1–6

Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas

Topic review

DOI: 10.1007/s11060-008-9734-y

Cite this article as:
Sioka, C. & Kyritsis, A.P. J Neurooncol (2009) 92: 1. doi:10.1007/s11060-008-9734-y


Meningioma is a common intracranial tumor, originating from the meninges of the skull or spinal canal. Most meningiomas are benign tumors, however atypical or anaplastic tumors can be found in 6% of cases. Patients with asymptomatic small benign meningiomas can be followed without therapy, but in symptomatic patients complete surgical resection should be performed. For recurrent previously resected tumors re-resection is recommended followed by radiotherapy in selected cases. Antiprogesterone treatment can also be considered in recurrent benign meningiomas. Immunotherapy with interferon-alpha and chemotherapy should be reserved for all cases of recurrent meningiomas (benign, atypical, and malignant) when all the standard therapies have failed or contraindicated.


Chemotherapy Meningioma Progesterone Hydroxyurea Interferon 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  1. 1.Neurosurgical Research InstituteUniversity of Ioannina School of MedicineIoanninaGreece
  2. 2.Department of Nuclear MedicineUniversity Hospital of IoanninaIoanninaGreece
  3. 3.Department of NeurologyUniversity Hospital of IoanninaIoanninaGreece

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