Journal of Neuro-Oncology

, Volume 91, Issue 1, pp 107–111

A de novo desmoid tumor of the surgical site following foramen magnum meningioma resection in a patient with Gardner’s Syndrome: a case report and review of the literature

  • Tyler James Kenning
  • Vikramjit S. Kanwar
  • Jiang Qian
  • Eric M. Deshaies
Case Report

DOI: 10.1007/s11060-008-9684-4

Cite this article as:
Kenning, T.J., Kanwar, V.S., Qian, J. et al. J Neurooncol (2009) 91: 107. doi:10.1007/s11060-008-9684-4


Background Gardner’s Syndrome is a familial adenomatous polyposis (FAP) syndrome that presents with colorectal polyps, craniofacial osteomas, lipomas, epidermoid cysts, and ampullary cancers. These patients are at significant risk for developing desmoid tumors, which are locally infiltrating fibromatous lesions. These are most commonly found in the abdominal cavity, but may be extra-abdominal. Although FAP-associated desmoid tumors often occur at sites of surgical scarring, this is the first report following resection of an intracranial meningioma. Case description We present a patient with Gardner’s Syndrome who underwent resection of a foramen magnum meningioma and subsequently developed a de novo desmoid tumor at the surgical site. She had a complete surgical resection of the tumor but did not receive adjuvant therapy. At the time of her death 7 years after her desmoid tumor resection, she had no evidence of a recurrence at the skull base. Conclusion This case report emphasizes the need for careful follow-up in patients with Gardner’s Syndrome who undergo resection of a meningioma or other neurosurgical procedure. Adjuvant therapy may be of value in these patients.


Desmoid tumorForamen magnumGardner’s SyndromeMeningiomaSkull base

Abbreviations list


Adenomatous polyposis coli


Computed tomography


Deoxyribonucleic acid


Epithelial membrane antigen

H & E

Hematoxylin and eosin


Magnetic resonance imaging

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Tyler James Kenning
    • 1
  • Vikramjit S. Kanwar
    • 2
  • Jiang Qian
    • 3
  • Eric M. Deshaies
    • 1
  1. 1.Division of Neurosurgery, Department of SurgeryAlbany Medical CenterAlbanyUSA
  2. 2.Department of Pediatrics, Pediatric Hematology-OncologyChildren’s Hospital at Albany Medical CenterAlbanyUSA
  3. 3.Department of PathologyAlbany Medical CenterAlbanyUSA