Journal of Neuro-Oncology

, Volume 90, Issue 3, pp 351–355

M1 Medulloblastoma: high risk at any age

  • Robert P. Sanders
  • Arzu Onar
  • James M. Boyett
  • Alberto Broniscer
  • E. Brannon Morris
  • Ibrahim Qaddoumi
  • Gregory T. Armstrong
  • Frederick A. Boop
  • Robert A. Sanford
  • Larry E. Kun
  • Thomas E. Merchant
  • Amar Gajjar
Clinical study - patient Study

DOI: 10.1007/s11060-008-9671-9

Cite this article as:
Sanders, R.P., Onar, A., Boyett, J.M. et al. J Neurooncol (2008) 90: 351. doi:10.1007/s11060-008-9671-9

Abstract

Background: The prognosis for children with M1 medulloblastoma (positive CSF cytology) has not been well-defined. Methods: We retrospectively reviewed the records of 285 newly diagnosed medulloblastoma patients treated between 1984 and 2006. Older children received post-operative craniospinal and tumor bed irradiation; radiotherapy for younger children depended on treatment era and physician/family preference. Results: 55 patients were <3 years old and 230 patients were ≥ 3 years old at diagnosis. We detected significant (P < 0.0001) associations between M1 disease and EFS for the entire cohort and for both younger and older patients. Among younger children, M1 patients had lower EFS than M0 (P = 0.0044). Conclusions: Children <3 years old with M1 medulloblastoma fared poorly in our small series. Survival for older children with M1 disease treated with higher-dose CSI was better than that of M2/M3 patients, but still less than optimal; our findings do not support reduction in therapy for either cohort.

Keywords

Medulloblastoma Cytology Infant Survival Metastatic Prognosis 

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Robert P. Sanders
    • 1
    • 6
  • Arzu Onar
    • 2
  • James M. Boyett
    • 2
  • Alberto Broniscer
    • 1
  • E. Brannon Morris
    • 1
  • Ibrahim Qaddoumi
    • 1
  • Gregory T. Armstrong
    • 3
  • Frederick A. Boop
    • 4
  • Robert A. Sanford
    • 4
  • Larry E. Kun
    • 5
  • Thomas E. Merchant
    • 5
  • Amar Gajjar
    • 1
  1. 1.Department of OncologySt. Jude Children’s Research HospitalMemphisUSA
  2. 2.Department of BiostatisticsSt. Jude Children’s Research HospitalMemphisUSA
  3. 3.Department of Epidemiology and Cancer ControlSt. Jude Children’s Research HospitalMemphisUSA
  4. 4.Department of NeurosurgeryUniversity of Tennessee Health Sciences CenterMemphisUSA
  5. 5.Department of Radiological SciencesSt. Jude Children’s Research HospitalMemphisUSA
  6. 6.San AntonioUSA

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