Journal of Neuro-Oncology

, Volume 90, Issue 1, pp 47–51

FDG-PET to predict different patterns of progression in multicentric glioblastoma: a case report

  • Cécile Colavolpe
  • Eric Guedj
  • Philippe Metellus
  • Maryline Barrie
  • Dominique Figarella-Branger
  • Olivier Mundler
  • Olivier Chinot
Clinical-Patient Studies

DOI: 10.1007/s11060-008-9629-y

Cite this article as:
Colavolpe, C., Guedj, E., Metellus, P. et al. J Neurooncol (2008) 90: 47. doi:10.1007/s11060-008-9629-y

Abstract

True multicentric glioblastoma multiforme (GBM) is rare and consists of separate distinct tumors in different cerebral lobes or hemispheres without any apparent route of dissemination. Few data are available describing its imaging using positron emission tomography (PET) with [18F]-fluoro-2-deoxy-d-glucose (FDG). In this paper, we report on the case of a man with bifocal tumor in the right frontal and temporal lobes who underwent FDG-PET imaging. Visual and semiquantitative analysis showed two different metabolic patterns with much more intense uptake in the smaller temporal lesion. Subtotal surgical removal of the main frontal lesion allowed satisfactory control in the operative site, whereas the temporal lesion was rapidly progressive with occurrence of necrosis, which led to a second neurosurgery. The diagnosis of glioblastoma was confirmed by neuropathological examination in both cases but with much higher immunohistochemical expression of O6-methylguanine-DNA-methyltransferase (MGMT) in the temporal lesion. This report illustrates the potential interest of FDG-PET in multicentric GBMs to identify different metabolic patterns, in accordance with clinical, morphological, and molecular aggressiveness.

Keywords

Brain tumorFluorodeoxyglucose F18Glioblastoma multiformeMulticentric gliomasPositron emission tomography

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Cécile Colavolpe
    • 1
  • Eric Guedj
    • 1
  • Philippe Metellus
    • 2
  • Maryline Barrie
    • 3
  • Dominique Figarella-Branger
    • 4
  • Olivier Mundler
    • 1
  • Olivier Chinot
    • 3
  1. 1.Department of Nuclear MedicineCentre Hospitalo-Universitaire de la Timone (CHU Timone)Marseille Cedex 5France
  2. 2.Department of NeurosurgeryCHU TimoneMarseille Cedex 5France
  3. 3.Department of Neuro-oncologyCHU TimoneMarseille Cedex 5France
  4. 4.Department of PathologyCHU TimoneMarseille Cedex 5France