Clinical-patient studies

Journal of Neuro-Oncology

, Volume 89, Issue 1, pp 59-62

First online:

Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease

  • Mohammad Sami WalidAffiliated withMedical Center of Central Georgia Email author 
  • , Earl Christopher TroupAffiliated withGreenville Hospital System University Medical Center, Southeastern Neurosurgical & Spine Institute

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Introduction Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000. We are presenting a young patient with Ollier Disease and high-grade astrocytoma. Case report A 14-year-old, Caucasian male with Ollier Disease presented with a history of headaches, vomiting, blurred vision, and unsteady gait. Brain MRI with contrast showed a 41 × 55 mm mass in the posterior fossa with spotty enhancement, which pathology proved to be anaplastic astrocytoma. Conclusion Despite the universal acceptance that Ollier Disease carries a high risk of developing malignancy there is very little in the literature about systematic screening. We recommended a cost-effective screening regime for these patients.


Ollier Astrocytoma Screening PTHR1 PTEN