Journal of Neuro-Oncology

, 85:171

Racial/ethnic differences in survival among elderly patients with a primary glioblastoma

Authors

    • Case Comprehensive Cancer CenterCase Western Reserve University School of Medicine
  • John L. Maldonado
    • H. Lee Moffitt Cancer Center and Research Institute
  • Vonetta L. Williams
    • H. Lee Moffitt Cancer Center and Research Institute
    • Department of Epidemiology and BiostatisticsUniversity of South Florida College of Public Health
  • William T. Curry
    • Department of Neurosurgery, Massachusetts General HospitalHarvard Medical School
  • Elizabeth A. Rodkey
    • H. Lee Moffitt Cancer Center and Research Institute
  • Frederick G. BarkerII
    • Department of Neurosurgery, Massachusetts General HospitalHarvard Medical School
  • Andrew E. Sloan
    • Case Comprehensive Cancer CenterCase Western Reserve University School of Medicine
Lab. Investigation-Human/Animal Tissue

DOI: 10.1007/s11060-007-9405-4

Cite this article as:
Barnholtz-Sloan, J.S., Maldonado, J.L., Williams, V.L. et al. J Neurooncol (2007) 85: 171. doi:10.1007/s11060-007-9405-4

Abstract

Background

Few studies have assessed racial/ethnic differences in survival after primary glioblastoma diagnosis. We investigate these differences, incorporating information on White, Hispanics and Asians, as well as White, non-Hispanics and Blacks, among elderly individuals with a primary glioblastoma utilizing the population-based Surveillance, Epidemiology and End Results (SEER) Program-Medicare linked database.

Methods

A total of 1,530 individuals diagnosed > = 66 years of age from 6/1/91 to 12/31/99 in the SEER data were linked with Medicare information from 1/1/91 to 12/31/01. All individuals had Medicare Parts A and B and were non-HMO for 6 months before and 12 months after diagnosis to gather pre-diagnosis co-morbidities and post-diagnosis first course of treatment. Survival differences by race/ethnicity and by race/ethnicity stratified by treatment type and/or median household income were examined using Kaplan–Meier and multivariable Cox proportional hazards models.

Results

Significant racial/ethnic differences existed between White, non-Hispanics and Blacks in marital status, income and SEER registry region for the entire US. In analysis limited to the West region, significant racial/ethnic differences existed for income only. Overall there were no differences in survival between White, non-Hispanics and Blacks, however, in analysis limited to the West region, Asians had a lower risk of death compared to White, non-Hispanics [HR = 0.67, 95% CI (0.43, 1.03)]. Asians who had multiple treatments also had a lower risk of death compared to White, non-Hispanics [HR = 0.65, 95% CI (0.41, 1.01)].

Conclusions

Racial/ethnic differences in survival after primary glioblastoma diagnosis exist and may be partially explained by racial/ethnic differences in treatment and income.

Keywords

ElderlyGlioblastomaRace/ethnicitySEER-medicareSurvival

Copyright information

© Springer Science+Business Media, LLC 2007