Journal of Neuro-Oncology

, Volume 84, Issue 3, pp 245–248

FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status

  • Gentian Kaloshi
  • Karima Mokhtari
  • Catherine Carpentier
  • Sophie Taillibert
  • Julie Lejeune
  • Yannick Marie
  • Jean-Yves Delattre
  • Roseline Godbout
  • Marc Sanson
Lab. Investigation-Human/Animal Tissue

DOI: 10.1007/s11060-007-9377-4

Cite this article as:
Kaloshi, G., Mokhtari, K., Carpentier, C. et al. J Neurooncol (2007) 84: 245. doi:10.1007/s11060-007-9377-4

Abstract

FABP7 expression has been analysed in a series of 123 glioblastomas (68 pure GBM, 55 GBMO, i.e. with oligodendroglial component). FABP7, found in 91/123 samples, showed a pure cytoplasmic expression in 69 cases, and cytoplasmic + nuclear expression in 22 cases. FABP7 expression was associated with pure GBM histology and shorter survival (15.7 months versus 21.5 months). Nuclear expression of FABP7 was more specifically related to EGFR amplification and more invasive tumors. These data, although they need to be confirmed by further studies, support the relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7.

Keywords

Glioblastoma GBMO FABP7 Invasion EGFR 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Gentian Kaloshi
    • 1
  • Karima Mokhtari
    • 2
    • 3
  • Catherine Carpentier
    • 3
  • Sophie Taillibert
    • 1
  • Julie Lejeune
    • 1
  • Yannick Marie
    • 3
  • Jean-Yves Delattre
    • 1
    • 3
  • Roseline Godbout
    • 4
  • Marc Sanson
    • 1
    • 3
    • 5
  1. 1.Service de Neurologie Mazarin, Assistance Publique-Hôpitaux de ParisGroupe Hospitalier Pitié-SalpêtrièreParis, Cedex 13France
  2. 2.Laboratoire de Neuropathologie Raymond Escourolle, Assistance Publique-Hôpitaux de ParisGroupe Hospitalier Pitié-SalpêtrièreParis, Cedex 13France
  3. 3.INSERM, U711, Biologie des Interactions Neurones & Glie, Faculté de MédecineUniversité Pierre et Marie CurieParis, 13France
  4. 4.Department of OncologyUniversity of AlbertaEdmontonCanada
  5. 5.Service de Neurologie MazarinGroupe Hospitalier Pitié-SalpêtrièreParisFrance

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