, Volume 83, Issue 1, pp 91-93
Date: 13 Dec 2006

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme

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Abstract

We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.