Letter to the Editor

Journal of Neuro-Oncology

, Volume 83, Issue 1, pp 91-93

First online:

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme

  • Ramon MartinezAffiliated withDepartment of Neurosurgery, University of DresdenDepartment of Neurosurgery, Klinikum Fulda, Acad. Hospital Philipps University of Marburg Email author 
  • , Gabriele SchackertAffiliated withDepartment of Neurosurgery, University of Dresden
  • , Ricard Yaya-TurAffiliated withMedical Oncology Department of Valencia
  • , Iñigo Rojas-MarcosAffiliated withNeurology Department, Hôpital Pitié-Salpetrière
  • , James G. HermanAffiliated withThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
  • , Manel EstellerAffiliated withCancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO) Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


We have performed a methylation-specific PCR approach to comparatively analyze the MGMT promoter methylation status in 186 glioblastomas (GBM) from patients with classic survival and nine from patients with long-term survival (LTS GBM). The methylation rate in LTS GBM was significantly higher (77.8% vs. 39.2%, = 0.033) which suggests that MGMT hypermethylation is a frequent hallmark of LTS GBM and contributes to characterize this intriguing GBM subtype.