Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma
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- Chamberlain, M.C., Glantz, M.J., Chalmers, L. et al. J Neurooncol (2007) 82: 81. doi:10.1007/s11060-006-9241-y
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Concurrent temozolomide (TMZ) and radiotherapy is the new standard of care for patients with newly diagnosed glioblastoma. In 51 consecutive patients treated according to this regimen, 7 patients (14%) manifested surgically confirmed early necrosis without evidence of recurrent tumor. This observation suggests that daily TMZ may represent a potent radiosensitizing regimen.