Journal of Neuro-Oncology

, Volume 72, Issue 2, pp 169–177

Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients

Authors

    • Department of Neuroradiology, Medical SchoolUniversity of Tübingen
    • Department of NeuroradiologyRadcliffe Infirmary
    • Department of NeuroradiologyThe Radcliffe Infirmary
  • Thomas Nägele
    • Department of Neuroradiology, Medical SchoolUniversity of Tübingen
  • Agnieska Korfel
    • Department of Hematology and OncologyUniversity Hospital Benjamin Franklin
  • Stefan Heckl
    • Department of Neuroradiology, Medical SchoolUniversity of Tübingen
  • Eckhard Thiel
    • Department of Hematology and OncologyUniversity Hospital Benjamin Franklin
  • Michael Bamberg
    • Department of Radiation Oncology, Medical SchoolUniversity of Tübingen
  • Michael Weller
    • Dep-artment of Neurology, Medical SchoolUniversity of Tübingen
  • Ulrich Herrlinger
    • Dep-artment of Neurology, Medical SchoolUniversity of Tübingen
Clinical Study

DOI: 10.1007/s11060-004-3390-7

Cite this article as:
Küker, W., Nägele, T., Korfel, A. et al. J Neurooncol (2005) 72: 169. doi:10.1007/s11060-004-3390-7

Abstract

To avoid an unnecessary extend of surgery in primary central nervous system lymphoma (PCNSL), the diagnosis should be suspected after MRI.

Pre-treatment MRI examinations of 100 immunologically competent patients with biopsy-proven PCNSL were evaluated. All patients had T2- and T1-weighted images with contrast enhancement. Diffusion-weighted MRI (DW-MRI) was available in 15, proton-MR-spectroscopy (1H-MRS) in four patients.

The number of lesions ranged from one (n=65 patients) to eight (n=1) with a mean of 1.7. The most frequent locations were the cerebral hemispheres (n=66), the basal ganglia (n=27) and the corpus callosum (n=24). In the 65 patients with a solitary lesion, hemispheric lesions were most frequent (n=23) followed by corpus callosum (n=18). Contrast enhancement was found in all but one patient. 1H-MRS revealed a uniformly pathologic pattern of metabolite concentrations in all patients.

Characteristic imaging features of PCNSL are contrast-enhancing lesions with a diameter of at least 15 mm in contact with the subarachnoid space. DW-MRI and proton spectroscopy may aid in differential diagnosis.

Keywords

brain neoplasmDW-MRIlymphomaMRIPCNSLspectroscopy

Copyright information

© Springer 2005