, Volume 42, Issue 9, pp 1032-1039
Date: 23 Oct 2012

Effects of Sleep Deprivation on Consolidation of Spatial Memory in Rats after One-Day Training in a Morris Water Maze

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The effects of sleep deprivation produced using a carousel method on the consolidation of spatial memory were studied in rats (male Wistar rats) after one-day training using the Frick et al. protocol (2000) in a Morris water maze. Data were obtained providing evidence that the memory trace after rapid 3-h training was retained for one day. Sleep deprivation for 24 h after training prevented reinforcement (consolidation) of spatial memory. The results led to the conclusion that a model based on one-day training can be used to study the neurophysiological and neurochemical mechanisms of the effects of sleep deprivation on consolidation of spatial memory.

Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 61, No. 3, pp. 322–331, May–June, 2011.