Effects of Sleep Deprivation on Consolidation of Spatial Memory in Rats after One-Day Training in a Morris Water Maze
- First Online:
- Cite this article as:
- Dorokhov, V.B., Kozhedub, R.G., Arseniev, G.N. et al. Neurosci Behav Physi (2012) 42: 1032. doi:10.1007/s11055-012-9675-y
- 314 Downloads
The effects of sleep deprivation produced using a carousel method on the consolidation of spatial memory were studied in rats (male Wistar rats) after one-day training using the Frick et al. protocol (2000) in a Morris water maze. Data were obtained providing evidence that the memory trace after rapid 3-h training was retained for one day. Sleep deprivation for 24 h after training prevented reinforcement (consolidation) of spatial memory. The results led to the conclusion that a model based on one-day training can be used to study the neurophysiological and neurochemical mechanisms of the effects of sleep deprivation on consolidation of spatial memory.