Neuroscience and Behavioral Physiology

, Volume 42, Issue 9, pp 1032–1039

Effects of Sleep Deprivation on Consolidation of Spatial Memory in Rats after One-Day Training in a Morris Water Maze

  • V. B. Dorokhov
  • R. G. Kozhedub
  • G. N. Arseniev
  • S. N. Kozhechkin
  • Yu. V. Ukraintseva
  • M. A. Kulikov
  • A. I. Manolov
  • V. M. Kovalzon
Article

DOI: 10.1007/s11055-012-9675-y

Cite this article as:
Dorokhov, V.B., Kozhedub, R.G., Arseniev, G.N. et al. Neurosci Behav Physi (2012) 42: 1032. doi:10.1007/s11055-012-9675-y
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The effects of sleep deprivation produced using a carousel method on the consolidation of spatial memory were studied in rats (male Wistar rats) after one-day training using the Frick et al. protocol (2000) in a Morris water maze. Data were obtained providing evidence that the memory trace after rapid 3-h training was retained for one day. Sleep deprivation for 24 h after training prevented reinforcement (consolidation) of spatial memory. The results led to the conclusion that a model based on one-day training can be used to study the neurophysiological and neurochemical mechanisms of the effects of sleep deprivation on consolidation of spatial memory.

Keywords

consolidation of spatial memory one-day training Morris water test sleep deprivation 

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • V. B. Dorokhov
    • 1
  • R. G. Kozhedub
    • 1
  • G. N. Arseniev
    • 1
  • S. N. Kozhechkin
    • 1
  • Yu. V. Ukraintseva
    • 1
  • M. A. Kulikov
    • 1
  • A. I. Manolov
    • 1
  • V. M. Kovalzon
    • 2
  1. 1.Institute of Higher Nervous Activity and NeurophysiologyRussian Academy of SciencesMoscowRussia
  2. 2.A. N. Severtsov Institute of Problems in Ecology and EvolutionRussian Academy of SciencesMoscowRussia