Article

Neuroscience and Behavioral Physiology

, Volume 36, Issue 6, pp 619-624

First online:

Gestational hypothyroxinemia and cognitive function in offspring

  • É. P. KasatkinaAffiliated withDepartment of Pediatric and Adolescent Endocrinology, Russian Postgraduate Medical Academy
  • , L. N. SamsonovaAffiliated withDepartment of Pediatric and Adolescent Endocrinology, Russian Postgraduate Medical Academy
  • , V. N. IvakhnenkoAffiliated withDepartment of Pediatric and Adolescent Endocrinology, Russian Postgraduate Medical Academy
  • , G. V. IbragimovaAffiliated withDepartment of Medical Radiology, Russian Postgraduate Medical Academy
  • , A. V. RyabykhAffiliated withDepartment of Medical Radiology, Russian Postgraduate Medical Academy
  • , L. L. NaumenkoAffiliated withDepartment of Pediatrics, Russian Postgraduate Medical Academy
  • , Yu. A. EvdokimovaAffiliated withDepartment of Obstetrics and Gynecology, Russian Postgraduate Medical Academy

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Abstract

The effects of gestational hypothyroxinemia on the neurointellectual prognosis of children in the first year of life living in an industrial city (megalopolis) with mild iodine deficiency were studied in 13 children of mothers with thyroid hormone-corrected gestational hypothyroxinemia in the first trimester and 10 children of mothers with normal levels of free thyroxine by assessing cognitive functions at ages six, nine, and 12 months using the Gnome mental development scale. The results showed that maternal free thyroxine levels at the early stages (5–9 weeks) of pregnancy correlated significantly with the coefficients of mental development among the children at ages 6, 9, and 12 months, i.e., represented one of the factors defining the neuropsychological development of offspring. Early (not later than nine weeks) correction of gestational hypothyroxinemia with levothyroxine at a mean daily dose of at lest 1.2 µg/kg improved the neurointellectual prognosis of the offspring, increasing the coefficient of mental development of children to 92–97 points during the first year of life, i.e., to the level of development of mental functions of children born to mothers with normal thyroxine levels.

Key words

maternal hypothyroxinemia pregnancy thyroid hormones neuropsychological development cognitive functions thyroid gland