Journal of Nanoparticle Research

, 16:2512

Gold nanoparticle shape effects on human serum albumin corona interface: a molecular dynamic study

Research Paper

DOI: 10.1007/s11051-014-2512-1

Cite this article as:
Ramezani, F., Amanlou, M. & Rafii-Tabar, H. J Nanopart Res (2014) 16: 2512. doi:10.1007/s11051-014-2512-1

Abstract

In recent years, there has been considerable progress in the design and study of gold nanoparticles that geared toward biomedical applications. In most imaging and therapeutic applications, gold nanoparticles enter the bloodstream directly by intravenous administration forming molecular complexes with encountered proteins termed as the protein corona. Since albumin is the most abundant protein in human blood plasma, in this study, gold nanoparticle interactions and its shape effects on human serum albumin were studied by molecular dynamic simulation. These results revealed that in the interaction of albumin with any shapes of gold nanoparticle, human serum albumin unfolds and helix amount decreases. Cubic gold nanoparticles showed stronger unfolding effects on the albumin than the spherical gold nanoparticles.

Keywords

GoldNanoparticleAlbuminMolecular dynamicGromacsProtein structureModeling and simulation

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Medical Physics and Biomedical EngineeringShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran