Research Paper

Journal of Nanoparticle Research

, 14:1218

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Novel ZnO-binding peptides obtained by the screening of a phage display peptide library

  • Piotr GolecAffiliated withLaboratory of Molecular Biology (affiliated with the University of Gdańsk), Institute of Biochemistry and Biophysics, Polish Academy of Sciences
  • , Joanna Karczewska-GolecAffiliated withLaboratory of Molecular Bacteriology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk
  • , Marcin ŁośAffiliated withDepartment of Molecular Biology, University of GdańskInstitute of Physical Chemistry Polish Academy of SciencesPhage Consultants
  • , Grzegorz WęgrzynAffiliated withDepartment of Molecular Biology, University of Gdańsk Email author 


Zinc oxide (ZnO) is a semiconductor compound with a potential for wide use in various applications, including biomaterials and biosensors, particularly as nanoparticles (the size range of ZnO nanoparticles is from 2 to 100 nm, with an average of about 35 nm). Here, we report isolation of novel ZnO-binding peptides, by screening of a phage display library. Interestingly, amino acid sequences of the ZnO-binding peptides reported in this paper and those described previously are significantly different. This suggests that there is a high variability in sequences of peptides which can bind particular inorganic molecules, indicating that different approaches may lead to discovery of different peptides of generally the same activity (e.g., binding of ZnO) but having various detailed properties, perhaps crucial under specific conditions of different applications.


Zinc oxide ZnO nanoparticles ZnO-binding peptides Phage display