Journal of Nanoparticle Research

, 14:1185

A novel method for synthesis of 56Co-radiolabelled silica nanoparticles

Authors

  • I. Cydzik
    • European Commission, Joint Research CentreInstitute for Health and Consumer Protection
    • Institute of Nuclear Chemistry and Technology
    • Heavy Ion LaboratoryUniversity of Warsaw
  • A. Bilewicz
    • Institute of Nuclear Chemistry and Technology
  • K. Abbas
    • European Commission, Joint Research CentreInstitute for Transuranium Elements (Ispra Site)
  • F. Simonelli
    • European Commission, Joint Research CentreInstitute for Health and Consumer Protection
  • A. Bulgheroni
    • European Commission, Joint Research CentreInstitute for Health and Consumer Protection
    • European Commission, Joint Research CentreInstitute for Health and Consumer Protection
  • N. Gibson
    • European Commission, Joint Research CentreInstitute for Health and Consumer Protection
Research Paper

DOI: 10.1007/s11051-012-1185-x

Cite this article as:
Cydzik, I., Bilewicz, A., Abbas, K. et al. J Nanopart Res (2012) 14: 1185. doi:10.1007/s11051-012-1185-x

Abstract

A method for synthesis of radiolabelled amorphous silica nanoparticles is presented. The method is based on the well-known Stöber process with the exception that 56Co radiotracer is introduced into one of the precursor materials prior to the initiation of the nanoparticle synthesis. The 56Co was prepared by proton irradiation of an iron foil, followed by dissolution in hydrochloric acid and 56Co/Fe radiochemical separation. In order to determine the residual Fe in the 56Co radiotracer solution, ICP-MS measurements were performed. Nanoparticles in the size range 20–100 nm were synthesised and characterised by gamma spectrometry, ICP-MS, XRD, DLS, and Zeta potential measurement. It was shown that the size and Zeta potential of the nanoparticles was roughly the same following synthesis with or without added 56Co, and in both cases, the structure was that of amorphous silica. It was found that 99.5 % of the 56Co was bound into the nanoparticles during synthesis, and centrifugation experiments confirmed that the radiolabels were stably incorporated into the silica matrix.

Keywords

Silica nanoparticlesRadiolabelling of nanoparticlesRadiochemical synthesisRadiotracer

Copyright information

© Springer Science+Business Media B.V. 2012