Journal of Nanoparticle Research

, 14:932

Polyol-synthesized Zn0.9Mn0.1S nanoparticles as potential luminescent and magnetic bimodal imaging probes: synthesis, characterization, and toxicity study

Authors

  • M. Gaceur
    • ITODYS, Université Paris Diderot, Sorbonne Paris Cité
    • ITODYS, Université Paris Diderot, Sorbonne Paris Cité
  • M. Hemadi
    • ITODYS, Université Paris Diderot, Sorbonne Paris Cité
  • S. Nowak
    • ITODYS, Université Paris Diderot, Sorbonne Paris Cité
  • N. Menguy
    • IMPMC, Université Pierre et Marie Curie
  • J. P. Quisefit
    • LISA, Université Paris Diderot, Université Paris Est Créteil
  • K. David
    • ERRMECe EA1391, Institut des MatériauxUniversité de Cergy-Pontoise
  • T. Jahanbin
    • INSERM U-825, Pavillon Baudot
    • Université de Toulouse
  • S. Benderbous
    • INSERM U-825, Pavillon Baudot
    • Université de Toulouse
  • M. Boissière
    • ERRMECe EA1391, Institut des MatériauxUniversité de Cergy-Pontoise
    • ITODYS, Université Paris Diderot, Sorbonne Paris Cité
Research Paper

DOI: 10.1007/s11051-012-0932-3

Cite this article as:
Gaceur, M., Giraud, M., Hemadi, M. et al. J Nanopart Res (2012) 14: 932. doi:10.1007/s11051-012-0932-3

Abstract

We report here the synthesis, by the polyol method, of Mn-doped ZnS nanocrystals with the zinc blende structure. Phase transfer of the as-produced quantum dots from organic solvent into water was achieved by surface complexation with mercaptoacetate ligands. The magnetic and optical properties of the powders and aqueous colloids obtained were evaluated by SQUID magnetometry as well as electronic absorption and emission spectroscopies, to test their potential as magnetic and luminescent bimodal probes for medical imaging. With a 10 % concentration of Mn2+, the nanoparticles are paramagnetic at body temperature, and the aqueous colloids they form have high relaxivity with a r1 value of 20 mM−1 s−1 at 3 T. They are highly luminescent with a blue–green emission on 405-nm excitation. Viability assays and genotoxicity tests on Chinese hamster ovarian cells revealed neither acute cellular death, nor cell toxicity, nor damage to the nucleus after exposure for 24 h to particle doses of up to 100 μg mL−1.

Keywords

Quantum dotsMn–ZnSLuminescence propertiesParamagnetismMRI contrast agentsCytotoxicityEnvironmental and health effects

Copyright information

© Springer Science+Business Media B.V. 2012