Journal of Nanoparticle Research

, Volume 13, Issue 6, pp 2375–2386

Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method

Research Paper

DOI: 10.1007/s11051-010-9998-y

Cite this article as:
Liu, D., Jiang, S., Shen, H. et al. J Nanopart Res (2011) 13: 2375. doi:10.1007/s11051-010-9998-y

Abstract

The preparation of solid lipid nanoparticles (SLNs) suffers from the drawback of poor incorporation of water-soluble drugs. The aim of this study was therefore to assess various formulation and process parameters to enhance the incorporation of a water-soluble drug (diclofenac sodium, DS) into SLNs prepared by the emulsion/solvent evaporation method. Results showed that the entrapment efficiency (EE) of DS was increased to approximately 100% by lowering the pH of dispersed phase. The EE of DS-loaded SLNs (DS-SLNs) had been improved by the existence of cosurfactants and increment of PVA concentration. Stabilizers and their combination with PEG 400 in the dispersed phase also resulted in higher EE and drug loading (DL). EE increased and DL decreased as the phospholipid/DS ratio became greater, while the amount of DS had an opposite effect. Ethanol turned out to be the ideal solvent making DS-SLNs. EE and DL of DS-SLNs were not affected by either the stirring speed or the viscosity of aqueous and dispersed phase. According to the investigations, drug solubility in dispersion medium played the most important role in improving EE.

Keywords

Solid lipid nanoparticlesEntrapment efficiencyDrug loadingEmulsion/solvent evaporationDiclofenac sodiumWater-solubleDrug deliveryNanomedicine

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.School of PharmacyNanjing Medical UniversityNanjingPeople’s Republic of China
  2. 2.Neuro-Psychiatric InstituteNanjing Brain Hospital Affiliated to Nanjing Medical UniversityNanjingPeople’s Republic of China