Journal of Nanoparticle Research

, Volume 10, Issue 6, pp 925-934

First online:

Preparation of nanoparticles by continuous-flow microfluidics

  • Andreas JahnAffiliated withNational Institute of Standards and TechnologyUniversity of Maryland Email author 
  • , Joseph E. ReinerAffiliated withNational Institute of Standards and Technology
  • , Wyatt N. VreelandAffiliated withNational Institute of Standards and Technology
  • , Don L. DeVoeAffiliated withUniversity of Maryland
  • , Laurie E. LocascioAffiliated withNational Institute of Standards and Technology
  • , Michael GaitanAffiliated withNational Institute of Standards and Technology

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We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate microscale and nanoscale particles has been reported. Here we emphasize the use of microfluidics, specifically microfluidic systems that operate in a continuous flow mode, thereby allowing continuous generation of desired particle formulations. The generation of semiconductor quantum dots, metal colloids, emulsions, and liposomes is considered. To emphasize the potential benefits of the continuous-flow microfluidic methodology for nanoparticle generation, preliminary data on the size distribution of liposomes formed using the microfluidic approach is compared to the traditional bulk alcohol injection method.


Nanoparticles Continuous flow microfluidics Particle formation Liposomes Emulsions Metal colloids Nanomanufacturing