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Preparation of nanoparticles by continuous-flow microfluidics

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Abstract

We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate microscale and nanoscale particles has been reported. Here we emphasize the use of microfluidics, specifically microfluidic systems that operate in a continuous flow mode, thereby allowing continuous generation of desired particle formulations. The generation of semiconductor quantum dots, metal colloids, emulsions, and liposomes is considered. To emphasize the potential benefits of the continuous-flow microfluidic methodology for nanoparticle generation, preliminary data on the size distribution of liposomes formed using the microfluidic approach is compared to the traditional bulk alcohol injection method.

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Authors and Affiliations

  1. National Institute of Standards and Technology, Gaithersburg, MD, USA

    Andreas Jahn, Joseph E. Reiner, Wyatt N. Vreeland, Laurie E. Locascio & Michael Gaitan

  2. University of Maryland, College Park, MD, USA

    Andreas Jahn & Don L. DeVoe

Authors
  1. Andreas Jahn
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  2. Joseph E. Reiner
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  3. Wyatt N. Vreeland
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  4. Don L. DeVoe
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  5. Laurie E. Locascio
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  6. Michael Gaitan
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Correspondence to Andreas Jahn.

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Official contribution of the National Institute of Standards and Technology; not subject to copyright in the United States of America.

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Jahn, A., Reiner, J.E., Vreeland, W.N. et al. Preparation of nanoparticles by continuous-flow microfluidics. J Nanopart Res 10, 925–934 (2008). https://doi.org/10.1007/s11051-007-9340-5

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  • DOI: https://doi.org/10.1007/s11051-007-9340-5

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