Multi-fueled approach to DNA nano-robotics
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- Nishikawa, A., Yaegashi, S., Tanaka, F. et al. Nat Comput (2008) 7: 371. doi:10.1007/s11047-008-9075-y
An approach to multi-fueled DNA nano-robotics is described. We propose three types of driving force (i.e., fuel for DNA nano-robots): thermal fuel, pH fuel, and light fuel. The thermal fuel controls the hybridization of DNA molecules around the melting temperature. The pH fuel controls the hybridization of the so-called i-motif by changing the pH condition. The light fuel controls the hybridization of DNA oligomers that are intercalated with azobenzene by irradiation with UV or visible light. These three fuels are not mutually exclusive. However, experimental conditions for the fueling of DNA nano-robots show efficacy. Concrete ideas for using these three fuel types are proposed and discussed. In addition, the results of calibration experiments and preliminary results for refining pH fuel sequence are also shown.
KeywordsAzobenzene DNA Nano-robotics i-Motif Light fuel Multi-fueled approach pH Fuel Thermal fuel
Stands for Black Hole Quencher type2
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