Natural Computing

, Volume 7, Issue 3, pp 371–383

Multi-fueled approach to DNA nano-robotics

  • Akio Nishikawa
  • Satsuki Yaegashi
  • Fumiaki Tanaka
  • Kazumasa Ohtake
  • Masami Hagiya
Article

DOI: 10.1007/s11047-008-9075-y

Cite this article as:
Nishikawa, A., Yaegashi, S., Tanaka, F. et al. Nat Comput (2008) 7: 371. doi:10.1007/s11047-008-9075-y

Abstract

An approach to multi-fueled DNA nano-robotics is described. We propose three types of driving force (i.e., fuel for DNA nano-robots): thermal fuel, pH fuel, and light fuel. The thermal fuel controls the hybridization of DNA molecules around the melting temperature. The pH fuel controls the hybridization of the so-called i-motif by changing the pH condition. The light fuel controls the hybridization of DNA oligomers that are intercalated with azobenzene by irradiation with UV or visible light. These three fuels are not mutually exclusive. However, experimental conditions for the fueling of DNA nano-robots show efficacy. Concrete ideas for using these three fuel types are proposed and discussed. In addition, the results of calibration experiments and preliminary results for refining pH fuel sequence are also shown.

Keywords

Azobenzene DNA Nano-robotics i-Motif Light fuel Multi-fueled approach pH Fuel Thermal fuel 

Abbreviations

BHQ2

Stands for Black Hole Quencher type2

RG

Stands for Rhodamine Green fluorescence group

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Akio Nishikawa
    • 1
  • Satsuki Yaegashi
    • 2
  • Fumiaki Tanaka
    • 3
    • 2
  • Kazumasa Ohtake
    • 4
    • 2
  • Masami Hagiya
    • 3
    • 2
  1. 1.Department of EconomicsFuji UniversityHanamakiJapan
  2. 2.Core Research for Evolution Science and Technology (CREST) Japan Science and Technology Agency (JST)KawaguchiJapan
  3. 3.Department of Computer ScienceUniversity of TokyoTokyoJapan
  4. 4.Department of BiochemistryUniversity of TokyoTokyoJapan

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