Mycopathologia

, Volume 169, Issue 6, pp 427–430

Clinical Comparison of Two Mexican Coccidioidins

  • Laura Rosío Castañón-Olivares
  • Rafael Laniado-Laborín
  • Toriello Concepcion
  • Bertha Muñoz-Hernández
  • Arturo Aroch-Calderón
  • Iván Sammir Aranda-Uribe
  • María Antonieta Flores-Sánchez
  • María del Rocío González-Martínez
  • Alfonso Hernández-Navarez
  • María Eugenia Manjarrez-Zavala
  • Sandra Miranda-Mauricio
  • Gabriel Palma
  • Amelia Pérez-Mejía
Article

DOI: 10.1007/s11046-010-9280-y

Cite this article as:
Castañón-Olivares, L.R., Laniado-Laborín, R., Concepcion, T. et al. Mycopathologia (2010) 169: 427. doi:10.1007/s11046-010-9280-y

Abstract

Coccidioidin, an extract from the saprophytic mycelial form of Coccidioides spp., has been a very useful antigen preparation both for skin and serological tests for coccidioidomycosis. Unfortunately, coccidioidin is not currently available for skin testing in the United States. Coccidioidin has been produced commercially in Mexico by a vaccine and reagents laboratory of the Mexican Federal Government. It also has been produced at the Microbiology Laboratory of the Faculty of Medicine, Universidad Nacional Autónoma de México exclusively as an antigen for research projects. The objective of the study was to compare both coccidioidins in their reactivity and safety when applied in humans. One hundred and eighty-four volunteers were tested; median age was 33 (range 14–82). When the cutoff point is set in 5 mm, 88 subjects (47.8%) had a positive test for the commercial coccidioidin and 76 (41.3%; CI95% 0.50, 1.15; P = 0.20) were positive with the research antigen. Seventy-five subjects were positive for both antigens and 96 were negative for both. Fifty-nine subjects (31.3%) reported an adverse reaction after the application of the antigen; they were mostly very mild local reactions. Mexican research coccidioidin is a safe and reliable antigen that can be used for the detection of coccidioidomycosis infection in mammals.

Keywords

Coccidioidin Coccidioides spp Reactivity Safety Humans 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Laura Rosío Castañón-Olivares
    • 1
  • Rafael Laniado-Laborín
    • 2
  • Toriello Concepcion
    • 1
  • Bertha Muñoz-Hernández
    • 4
  • Arturo Aroch-Calderón
    • 1
  • Iván Sammir Aranda-Uribe
    • 3
  • María Antonieta Flores-Sánchez
    • 3
  • María del Rocío González-Martínez
    • 1
  • Alfonso Hernández-Navarez
    • 3
  • María Eugenia Manjarrez-Zavala
    • 1
  • Sandra Miranda-Mauricio
    • 1
  • Gabriel Palma
    • 1
  • Amelia Pérez-Mejía
    • 1
  1. 1.Micología Médica, Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico CityMexico
  2. 2.Facultad de MedicinaUniversidad Autónoma de Baja CaliforniaTijuanaMéxico
  3. 3.Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico CityMexico
  4. 4.Instituto Nacional de Enfermedades RespiratoriasMexico CityMexico