, 166:117

First online:

Effects on Tyrosinase Activity by the Extracts of Ganoderma lucidum and Related Mushrooms

  • Chih-Ching ChienAffiliated withGraduate School of Biotechnology and Bioengineering, Yuan Ze University Email author 
  • , Mei-Ling TsaiAffiliated withGraduate School of Biotechnology and Bioengineering, Yuan Ze UniversityBiotechnology Center, Grape King Inc.
  • , Chin-Chu ChenAffiliated withBiotechnology Center, Grape King Inc.
  • , Shing-Jyh ChangAffiliated withDepartment of Obstetrics and Gynecology, Hsinchu Mackay Memorial HospitalCollege of Life Science, National Tsing Hua University
  • , Ching-Hui TsengAffiliated withChing-Hui Chinese Medical Clinic

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The inhibitory effects on tyrosinase activity by extracts of several mushrooms belonging to Basidiomycetes were evaluated. Among the tested mushrooms (Ganoderma lucidum, Antrodia camphorata, Agaricus brasiliensis, and Cordyceps militaris), G. lucidum exhibited significant inhibition of tyrosinase activity (IC50 value 0.32 mg/ml), compared to those prepared from other Basidiomycetes. Tyrosinase inhibitors are effective components of skin-lightening compounds and other cosmetics; currently many of the facial mask cosmetics in the market contain Ganoderma extracts in their ingredients. The finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their ‘healing’ properties in various Chinese traditional herbal on skin care products.


Ganoderma lucidum Lingzhi Medicinal mushroom Tyrosinase