, 166:117

Effects on Tyrosinase Activity by the Extracts of Ganoderma lucidum and Related Mushrooms


    • Graduate School of Biotechnology and BioengineeringYuan Ze University
  • Mei-Ling Tsai
    • Graduate School of Biotechnology and BioengineeringYuan Ze University
    • Biotechnology CenterGrape King Inc.
  • Chin-Chu Chen
    • Biotechnology CenterGrape King Inc.
  • Shing-Jyh Chang
    • Department of Obstetrics and GynecologyHsinchu Mackay Memorial Hospital
    • College of Life ScienceNational Tsing Hua University
  • Ching-Hui Tseng
    • Ching-Hui Chinese Medical Clinic

DOI: 10.1007/s11046-008-9128-x

Cite this article as:
Chien, C., Tsai, M., Chen, C. et al. Mycopathologia (2008) 166: 117. doi:10.1007/s11046-008-9128-x


The inhibitory effects on tyrosinase activity by extracts of several mushrooms belonging to Basidiomycetes were evaluated. Among the tested mushrooms (Ganodermalucidum, Antrodia camphorata, Agaricus brasiliensis, and Cordyceps militaris), G. lucidum exhibited significant inhibition of tyrosinase activity (IC50 value 0.32 mg/ml), compared to those prepared from other Basidiomycetes. Tyrosinase inhibitors are effective components of skin-lightening compounds and other cosmetics; currently many of the facial mask cosmetics in the market contain Ganoderma extracts in their ingredients. The finding that mushroom extracts contain tyrosinase activity inhibition will contribute to better understanding of how their ‘healing’ properties in various Chinese traditional herbal on skin care products.


Ganoderma lucidumLingzhiMedicinal mushroomTyrosinase

Copyright information

© Springer Science+Business Media B.V. 2008